Cucurbits plants: A key emphasis to its pharmacological potential
| Autor: | Javad Sharifi-Rad, Miquel Martorell, Shabnum Shaheen, Surjit Sen, Natália Martins, Célia F. Rodrigues, Senem Kamiloglu, Renu Suyal, Bahare Salehi, Hubert Antolak, Lalit Giri, Daniela Calina, Ewelina Pawlikowska, Esra Capanoglu, Farukh Sharopov, Anca Oana Docea, Gizem Catalkaya, Dorota Kregiel, Zeliha Selamoglu, Mehwish Jaffer, Nabil Adrar, Krishnendu Acharya, Arun K. Jugran, Raffaele Capasso |
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| Přispěvatelé: | Instituto de Investigação e Inovação em Saúde, Salehi, Bahare, Capanoglu, Esra, Adrar, Nabil, Catalkaya, Gizem, Shaheen, Shabnum, Jaffer, Mehwish, Giri, Lalit, Suyal, Renu, Jugran, Arun K., Calina, Daniela, Docea, Anca Oana, Kamiloglu, Senem, Kregiel, Dorota, Antolak, Hubert, Pawlikowska, Ewelina, Sen, Surjit, Acharya, Krishnendu, Selamoglu, Zeliha, Sharifi-Rad, Javad, Martorell, Miquel, Rodrigues, Célia F., Sharopov, Farukh, Martins, Natália, Capasso, Raffaele |
| Jazyk: | angličtina |
| Rok vydání: | 2019 |
| Předmět: |
Squash
antioxidant Pharmaceutical Science Review Analytical Chemistry 0302 clinical medicine Cucurbitacins cucurbits Drug Discovery Antioxidants / chemistry cucurbit Carotenoid Antineoplastic Agents Phytogenic / chemistry 2. Zero hunger chemistry.chemical_classification 0303 health sciences Traditional medicine food and beverages Antimicrobial Cucurbitacins / pharmacology 3. Good health Anticancer Chemistry (miscellaneous) Cucurbita / chemistry 030220 oncology & carcinogenesis Plant species Molecular Medicine Antioxidant Blood Glucose / drug effects Cucurbitacins / chemistry Anti-Infective Agents / pharmacology Clinical effectiveness Plant Extracts / chemistry squash Biology anticancer traditional medicine lcsh:QD241-441 03 medical and health sciences Triterpenoid lcsh:Organic chemistry pumpkin Humans Cucurbita Physical and Theoretical Chemistry 030304 developmental biology Cucurbits Antioxidants / pharmacology Antineoplastic Agents Phytogenic / pharmacology Organic Chemistry Anti-Infective Agents / chemistry biology.organism_classification Terpenoid chemistry Ethnopharmacology antimicrobial Medicine Traditional Pumpkin |
| Zdroj: | Molecules, Vol 24, Iss 10, p 1854 (2019) Molecules |
| Popis: | Cucurbita genus has received a renowned interest in the last years. This plant species, native to the Americas, has served worldwide folk medicine for treating gastrointestinal diseases and intestinal parasites, among other clinical conditions. These pharmacological effects have been increasingly correlated with their nutritional and phytochemical composition. Among those chemical constituents, carotenoids, tocopherols, phenols, terpenoids, saponins, sterols, fatty acids, and functional carbohydrates and polysaccharides are those occurring in higher abundance. However, more recently, a huge interest in a class of triterpenoids, cucurbitacins, has been stated, given its renowned biological attributes. In this sense, the present review aims to provide a detailed overview to the folk medicinal uses of Cucurbita plants, and even an in-depth insight on the latest advances with regards to its antimicrobial, antioxidant and anticancer effects. A special emphasis was also given to its clinical effectiveness in humans, specifically in blood glucose levels control in diabetic patients and pharmacotherapeutic effects in low urinary tract diseases. This work was supported by CONICYT PIA/APOYO CCTE AFB170007. N. Martins would like to thank the Portuguese Foundation for Science and Technology (FCT-Portugal) for the Strategic project ref. UID/BIM/04293/2013 and “NORTE2020—Northern Regional Operational Program” (NORTE-01-0145-FEDER-000012) and C.F.R. for the project UID/EQU/00511/2019—Laboratory for Process Engineering, Environment, Biotechnology, and Energy—LEPABE funded by national funds through FCT/MCTES (PIDDAC). |
| Databáze: | OpenAIRE |
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