Head and neck cancer: detection of recurrence with PET and 2-[F-18]fluoro-2-deoxy-D-glucose
| Autor: | Timo Kurki, Maria Lapela, Merja Haaparanta, Sirkku Leskinen, Paula Lindholm, Ulla Ruotsalainen, Heikki Minn, H. Joensuu, Reidar Grénman |
|---|---|
| Rok vydání: | 1995 |
| Předmět: |
Male
Larynx Visual interpretation Standardized uptake value Deoxyglucose Malignancy chemistry.chemical_compound Fluorodeoxyglucose F18 medicine Humans Radiology Nuclear Medicine and imaging medicine.diagnostic_test business.industry Head and neck cancer medicine.disease medicine.anatomical_structure chemistry Head and Neck Neoplasms Positron emission tomography Tracer uptake Female Neoplasm Recurrence Local Nuclear medicine business 2-Deoxy-D-glucose Tomography Emission-Computed |
| Zdroj: | Radiology. 197:205-211 |
| ISSN: | 1527-1315 0033-8419 |
| DOI: | 10.1148/radiology.197.1.7568825 |
| Popis: | To evaluate positron emission tomography (PET) with 2-[fluorine-18]fluoro-2-deoxy-D-glucose (FDG) in detection of suspected recurrence of head and neck cancer, and to compare visual, static, and kinetic analyses of the tracer uptake.Seventeen dynamic FDG PET studies were performed in 15 patients. The images were interpreted visually, and the uptake was quantitated as the standardized uptake value (SUV) and as the regional FDG metabolic rate.Sensitivity of blinded visual interpretation of the PET images for the presence of malignancy was 88% and specificity was 86%. Malignant lesions accumulated significantly more FDG than benign lesions (P = .008 for SUVs, P = .002 for regional metabolic rates). When maximum uptake of FDG in the benign lesions was used as a threshold, the sensitivity of SUV analysis for malignancy was 75% and that of regional metabolic rates was 86%.Detection of recurrent head and neck cancer is feasible with FDG PET. Quantitation of FDG uptake assists in correct interpretation of the PET images. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
|