Ginkgo biloba extract (GbE) attenuates obesity and anxious/depressive-like behaviours induced by ovariectomy
| Autor: | Suzete Maria Cerutti, Heider Mendonça de Andrade, Meira M. F. Machado, Lila Missae Oyama, Jéssica de Souza Figueiredo Borges Ribeiro, Bruna Kelly Sousa Hirata, Monica Marques Telles, Renata Mancini Banin, Lorenza Oliveira Testa Carvalho, Iracema Senna de Andrade, Eliane Beraldi Ribeiro, Viviane da Silva Júlio |
|---|---|
| Rok vydání: | 2021 |
| Předmět: |
0301 basic medicine
medicine.medical_specialty Elevated plus maze Science Ovariectomy Blood lipids Anxiety Article Elevated Plus Maze Test 03 medical and health sciences 0302 clinical medicine Internal medicine medicine Animals Obesity Rats Wistar Multidisciplinary biology Adiponectin medicine.diagnostic_test Depression Plant Extracts Ginkgo biloba business.industry Leptin Endocrine system and metabolic diseases medicine.disease biology.organism_classification Rats Menopause Metabolism 030104 developmental biology Endocrinology Ovariectomized rat Medicine Female business Lipid profile 030217 neurology & neurosurgery |
| Zdroj: | Scientific Reports Scientific Reports, Vol 11, Iss 1, Pp 1-14 (2021) |
| ISSN: | 2045-2322 |
| Popis: | While several pieces of evidence link obesity and mood disorders in menopause, the mechanisms involved are not yet fully understood. We have previously demonstrated that Ginkgo biloba extract (GbE) both attenuated diet-induced obesity of male rats and restored serotonin-induced hypophagia in ovariectomized female rats. The present study aimed at exploring whether GbE treatment ameliorates ovariectomy-related obesity and anxious/depressive-like behaviours. Wistar female rats were either ovariectomized (OVX) or sham-operated (Sham). After 2 months, either 500 mg/kg of GbE or vehicle were administered daily by gavage for 14 days. Anxious/depressive-like behaviours were assessed by the Elevated Plus Maze and the Forced Swim Tests, respectively. Ovariectomy caused high visceral adiposity, hyperleptinemia, and hypercholesterolemia, and increased the anxiety index (p = 0.048 vs. Sham + GbE) while it decreased the latency to immobility (p = 0.004 vs. Sham). GbE treatment in OVX rats improved body composition, adiponectin levels and blood lipid profile. It also reduced the anxiety index (p = 0.004) and increased the latency to immobility (p = 0.003) of OVX rats. Linear regression analysis demonstrated that leptin (p = 0.047) and total cholesterol levels (p = 0.022) were associated with anxious-like behaviours while body adiposity (p = 0.00005) was strongly associated with depressive-like behaviours. The results showed that GbE therapy was effective in attenuating the deleterious effects of ovariectomy on body composition, lipid profile, and anxious/depressive-like behaviours. Further studies are warranted to better understand the therapeutic potential of GbE in menopause. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
|