Inductively Coupled Plasma Mass Spectrometry-A Valid Method for the Characterization of Metal Conjugates in View of the Development of Radiopharmaceuticals

Autor:	Rahel H. Wallimann, Patrick Schindler, Heloïse Hensinger, Viviane J. Tschan, Sarah D. Busslinger, Rainer Kneuer, Cristina Müller, Roger Schibli
Jazyk:	angličtina
Rok vydání:	2023
Předmět:	γ-counting metal conjugates Drug Discovery cancer research Pharmaceutical Science Molecular Medicine ICP-MS radiopharmaceuticals PSMA-617
Zdroj:	Molecular Pharmaceutics, 20 (4)
ISSN:	1543-8384 1543-8392
DOI:	10.3929/ethz-b-000603766
Popis:	This study addresses the question whether in-ductively coupled plasma mass spectrometry (ICP-MS) can be used as a method for the in vitro and in vivo characterization of non-radioactive metal conjugates to predict the properties of analogous radiopharmaceuticals. In a "proof-of-concept" study, the prostate-specific membrane antigen (PSMA)-targeting [175Lu]Lu-PSMA-617 and [159Tb]Tb-PSMA-617 were compared with their respective radiolabeled analogues, [177Lu]Lu-PSMA-617 (PLU-VICTO, Novartis) and [161Tb]Tb-PSMA-617. ICP-MS and conventional gamma-counting of the cell samples revealed almost identical results ( Molecular Pharmaceutics, 20 (4) ISSN:1543-8384 ISSN:1543-8392
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c9b972985462646e270026444bc1106f Zobrazit plný text záznamu