Feasibility and usefulness of recommended screenings at long-term follow-up clinics for hematopoietic cell transplant survivors
| Autor: | Ikue Okuda, Chitose Ogawa, Takao Ueno, Masako Ikeda, Yuko Matsuba, Sung-Won Kim, Yukiko Aihara, Saiko Kurosawa, Yoshihiro Inamoto, Shigeo Fuji, Ayumu Ito, Takahiro Fukuda, Ayako Mori, Mayumi Tsukagoshi, Takashi Tanaka, Takuya Yamashita, Takuhiro Yamaguchi, Yutaka Saito |
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| Rok vydání: | 2021 |
| Předmět: |
education.field_of_study
Pediatrics medicine.medical_specialty Hematopoietic cell medicine.diagnostic_test business.industry Incidence (epidemiology) Population Psychological intervention Hematopoietic Stem Cell Transplantation Colonoscopy Transplantation Oncology Outpatient clinic Medicine Feasibility Studies Humans Prospective Studies Survivors Prospective cohort study business education Follow-Up Studies |
| Zdroj: | Supportive care in cancer : official journal of the Multinational Association of Supportive Care in Cancer. 30(3) |
| ISSN: | 1433-7339 |
| Popis: | PURPOSE Advances in allogeneic hematopoietic cell transplantation (allo-HCT) have resulted in a growing number of transplant survivors; however, long-term survivors are at risk of developing late complications, and published guidelines recommend screening of this population. We conducted a single-center prospective study to evaluate the adherence to and usefulness of recommended screenings at a long-term follow-up (LTFU) clinic. METHODS We included consecutive patients who received allo-HCT at our center from 2014, as well as post-HCT patients visiting our outpatient clinic. Visits and screenings were planned at 3 months, 6 months, and 1 year after allo-HCT, and annually thereafter. Outcomes were reported by physicians including the incidence of findings at each screening that led to interventions. RESULTS Among the 216 participants, 95% visited the LTFU clinic, and 94% completed planned screenings. However, the rate of secondary cancer screenings targeting high-risk subjects was lower (38% to 68%). The overall percentage of screening results leading to interventions was 4.5%, with higher percentages (> 10%) for bone density testing, ophthalmological examinations, dental assessment, upper gastrointestinal endoscopy, and colonoscopy, with two patients diagnosed with secondary cancers. CONCLUSIONS Although the overall screening rate was high, it should be possible to improve the detection rate of late complications by decreasing screening failures, especially the screening for secondary cancers limited for high-risk survivors. A nationwide effort to educate HCT survivors and health practitioners using standardized nationwide LTFU tools may be effective, along with the development of institutional, local, and nationwide networks to maintain effective follow-up systems. |
| Databáze: | OpenAIRE |
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