MAIT cells ameliorate liver fibrosis by enhancing the cytotoxicity of NK cells in cholestatic murine models

Autor:	Xiang Jiang, Yanan Peng, Lan Liu, Youwei Wang, Mengting Li, Wenjie Li, Fengxing Huang, Chunlan Zheng, Fei Xu, Qian Hu, Wanhui Wei, Shouquan Dong, Qiu Zhao
Rok vydání:	2022
Předmět:	Liver Cirrhosis Killer Cells Natural Mice Disease Models Animal Cholestasis Hepatology Animals Mucosal-Associated Invariant T Cells
Zdroj:	Liver International. 42:2743-2758
ISSN:	1478-3231 1478-3223
Popis:	Mucosal-associated invariant T (MAIT) cells are innate-like lymphocytes that display a critical role in various liver diseases. However, the role of MAIT cells in cholestatic liver fibrogenesis remains obscure. Our study aims to assess the contribution of MAIT cells and underlying mechanisms during this process.Cholestatic murine models using MAIT cell-deficient (MR1Liver MAIT cells were more activated with increased cytokines in cholestatic mice models than in control mice, although their frequency was decreased. MAIT cell deficiency led to severe liver inflammation and fibrosis with more activated HSCs in cholestatic mice. In addition, MR1Our findings indicate that MAIT cells ameliorate cholestatic liver fibrosis by enhancing the cytotoxicity of NK cells against HSCs. An in-depth understanding of the MAIT cell-mediated regulatory effect will provide more valuable immunotherapy strategies to treat liver fibrosis.
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c9b790970254ca39f960c64825651ee2 https://doi.org/10.1111/liv.15445 Zobrazit plný text záznamu Plný text ve formátu PDF Plný text ve formátu HTML
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