Familial Clustering of High Factor VIII Levels in Patients With Venous Thromboembolism
Autor: | Franz Keller, B. Mansouri Taleghani, Christian M. Schambeck, D. Wahler, I. Haubitz, K. Hinney |
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Rok vydání: | 2001 |
Předmět: |
Adult
Male congenital hereditary and neonatal diseases and abnormalities animal diseases Blood Donors Malignancy Asymptomatic Pathogenesis Von Willebrand factor Thromboembolism hemic and lymphatic diseases medicine Coagulopathy Cluster Analysis Humans Thrombophilia Family Genetic Predisposition to Disease Aged Venous Thrombosis Pregnancy Factor VIII biology business.industry Vascular disease Family aggregation Middle Aged medicine.disease Immunology biology.protein Regression Analysis Female medicine.symptom Cardiology and Cardiovascular Medicine business |
Zdroj: | Arteriosclerosis, Thrombosis, and Vascular Biology. 21:289-292 |
ISSN: | 1524-4636 1079-5642 |
DOI: | 10.1161/01.atv.21.2.289 |
Popis: | Abstract —High levels of factor VIII (FVIII) but not von Willebrand factor (vWF) are known to increase the risk for venous thromboembolism. Whether high FVIII levels originate from hereditary defects or from acquired conditions remains unanswered. The objective of our study was to investigate whether there is evidence for familial clustering of elevated FVIII levels in families in which ≥1 member has been affected by a thromboembolic event and had reproducibly high FVIII levels. We investigated FVIII levels in 361 patients with previous venous thromboembolism. FVIII levels were measured by a chromogenic assay; the cutoff value was defined as the 98th percentile of FVIII plasma levels of 266 blood donors. vWF levels were determined by an enzyme immunoassay. After exclusion of known causes of FVIII elevation, such as the acute thrombotic event itself; inflammation; malignancy; liver, renal, or vascular disease; surgery; or pregnancy, we included 17 patients with unexplained, reproducibly high FVIII levels. The investigation was also extended to these patients’ relatives. Multiple regressive analysis of blood donors and asymptomatic family members showed that the affiliation with a family in which 1 member suffered from venous thromboembolism and had reproducibly high FVIII levels is the second most important predictor for FVIII levels. Familial clustering was analyzed by the Houwing-Duistermaat familial aggregation test. After adjustment for the influence of age, sex, blood group, and vWF, FVIII levels were significantly ( P =0.038) clustered within families. In conclusion, FVIII levels seem to be familially determined in families in which a member showed high FVIII levels after previous venous thromboembolism. |
Databáze: | OpenAIRE |
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