Diatomics: toward diatom functional genomics
| Autor: | Pascal J. Lopez, Uma Maheswari, Anton Montsant, Chris Bowler |
|---|---|
| Rok vydání: | 2005 |
| Předmět: |
0106 biological sciences
Materials science Proteome Research areas ved/biology.organism_classification_rank.species Biomedical Engineering Bioengineering Genomics Computational biology 010603 evolutionary biology 01 natural sciences 03 medical and health sciences General Materials Science Phaeodactylum tricornutum Model organism 030304 developmental biology Diatoms 0303 health sciences Expressed sequence tag biology ved/biology Chromosome Mapping General Chemistry Condensed Matter Physics biology.organism_classification Silicon based Diatom Gene Expression Regulation Functional genomics |
| Zdroj: | Journal of nanoscience and nanotechnology. 5(1) |
| ISSN: | 1533-4880 |
| Popis: | For diatom biologists one of the most interesting research areas over the next years will be in linking mathematical models for pattern formation with information derived from molecular genetic, biochemical, and physiological studies. A major goal of this research is to exploit diatom proficiency in biogenic silica formation to develop strategies for bio-inspired nanofabrication of silicon based materials. Development of high-throughput methods for the functional analysis of diatom genes is a key step toward this goal. In this article we review the different techniques available to investigate gene and protein function in diatoms. Furthermore, to make diatom research as effective as possible the research community must address the question of which diatom species should be developed as a model. Choice of a diatom model organism should be made on the basis of several criteria, such as the ease of genetic manipulation, ecological relevance, or biomineralization capability. Phaeodactylum tricornutum is one of the principal three species that are candidates for such a model. For this species we have accomplished the first large-scale analysis of 12000 expressed sequence tags (ESTs) and have organized it in a queryable database, Phaeodactylum tricornutum database (PtDB). A summary of the functional analysis of this EST collection is presented, and genes of particular interest are highlighted. |
| Databáze: | OpenAIRE |
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