Subclinical hepatic encephalopathy: proton MR spectroscopic abnormalities
| Autor: | B D Ross, Thomas Ernst, S Jacobson, Truda Shonk, F Villamil, Rex Moats, Roland Kreis, J Korula |
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| Rok vydání: | 1994 |
| Předmět: |
Adult
Liver Cirrhosis Male In vivo magnetic resonance spectroscopy medicine.medical_specialty Magnetic Resonance Spectroscopy Cirrhosis Glutamine Neuropsychological Tests Choline Double-Blind Method medicine Humans Radiology Nuclear Medicine and imaging Sche Hepatic encephalopathy Subclinical infection Brain Chemistry medicine.diagnostic_test business.industry Magnetic resonance imaging Middle Aged medicine.disease Hepatic Encephalopathy Female Radiology business Nuclear medicine Inositol |
| Zdroj: | Radiology. 193:457-463 |
| ISSN: | 1527-1315 0033-8419 |
| DOI: | 10.1148/radiology.193.2.7972763 |
| Popis: | To determine whether hydrogen-1 magnetic resonance (MR) spectroscopy of the brain allows detection of subclinical hepatic encephalopathy (SCHE).In a double-blind study, overt hepatic encephalopathy (HE) and SCHE (defined with clinical and neuropsychiatric tests) were compared by means of H-1 MR spectroscopic criteria--reduction in cerebral myo-inositol (2 standard deviations [SDs] from normal) and choline (2 SDs from normal) with or without increased cerebral glutamine (1 SD from normal)--in 20 patients with cirrhosis.Concordance between MR spectroscopic and neuropsychiatric test results was 94% (kappa = 0.84). MR spectroscopy allowed diagnosis of SCHE in nine of nine patients (100%) and of HE in seven of eight (88%). Myo-inositol depletion alone had 80%-85% sensitivity for detection of HE and SCHE.H-1 MR spectroscopy allows accurate diagnosis of SCHE, and the results suggest an important role for myo-inositol in psychomotor and visuopractic functions. |
| Databáze: | OpenAIRE |
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