Usefulness of Lipoprotein(a) for Predicting Clinical Outcomes After Endovascular Therapy for Aortoiliac Atherosclerotic Lesions
| Autor: | Yuya Utsugi, Atsushi Takahashi, Hiroyuki Hikita, Yuta Sudo, Shun Nakamura, Shun Nakagama, Masafumi Mizusawa, Tasuku Yamamoto, Takashi Ashikaga, Mitsuaki Isobe, Junichi Doi, Shigeki Kimura, Keiichi Hishikari |
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| Rok vydání: | 2017 |
| Předmět: |
Male
medicine.medical_specialty Time Factors medicine.medical_treatment Aortic Diseases 030204 cardiovascular system & hematology Iliac Artery Endovascular therapy 03 medical and health sciences 0302 clinical medicine Predictive Value of Tests Risk Factors Angioplasty medicine.artery Humans Medicine Radiology Nuclear Medicine and imaging 030212 general & internal medicine Aged Retrospective Studies biology business.industry Stent Lipoprotein(a) Atherosclerosis medicine.disease Common iliac artery Progression-Free Survival Up-Regulation Stenosis biology.protein Biomarker (medicine) Female Stents lipids (amino acids peptides and proteins) Surgery Radiology Cardiology and Cardiovascular Medicine business Angioplasty Balloon Biomarkers Lipoprotein |
| Zdroj: | Journal of Endovascular Therapy. 24:793-799 |
| ISSN: | 1545-1550 1526-6028 |
| DOI: | 10.1177/1526602817728068 |
| Popis: | To evaluate the usefulness of serum lipoprotein(a) as a biomarker of clinical outcomes after endovascular therapy (EVT) for atherosclerotic aortoiliac lesions.Serum lipoprotein(a) concentrations were measured at admission in 189 consecutive patients (median age 72 years; 160 men) with peripheral artery disease who underwent EVT for aortoiliac occlusive disease. The patients were dichotomized into 2 groups based on serum lipoprotein(a) levels ≤40 mg/dL (LOW; n=135) or40 mg/dL (HIGH; n=54). After EVT, the incidences of major adverse limb events (MALE) were analyzed. Predictors of MALE were sought with a Cox proportional hazards analysis; results are presented as the hazard ratio (HR) and 95% confidence interval.At the median follow-up of 33 months (interquartile range 11, 54), MALE occurred in 44 (23.3%) patients. The MALE-free survival estimate was significantly lower in patients in the HIGH group (55.6% vs 85.2%, p0.001). Independent predictors of MALE after EVT were hemodialysis (HR 2.23, 95% CI 1.04 to 4.78, p=0.039) and high lipoprotein(a) levels (HR 2.80, 95% CI 1.44 to 5.45, p=0.003).High lipoprotein(a) levels were associated with a higher incidence of MALE after EVT for patients with aortoiliac lesions. |
| Databáze: | OpenAIRE |
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