New insights on the biomineralisation process developing in human lungs around inhaled asbestos fibres
| Autor: | Fabrizio Bardelli, Elena Belluso, Giulia Veronesi, Laurent Charlet, Silvana Capella, Donata Bellis, Alessia Cedola |
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| Přispěvatelé: | Soft and Living Matter Laboratory (S.Li.M. Lab), CNR Istituto di Nanotecnologia (NANOTEC), National Research Council of Italy | Consiglio Nazionale delle Ricerche (CNR)-National Research Council of Italy | Consiglio Nazionale delle Ricerche (CNR), Laboratoire de Chimie et Biologie des Métaux (LCBM - UMR 5249), Institut de Chimie du CNRS (INC)-Centre National de la Recherche Scientifique (CNRS)-Université Grenoble Alpes [2016-2019] (UGA [2016-2019])-Institut de Recherche Interdisciplinaire de Grenoble (IRIG), Direction de Recherche Fondamentale (CEA) (DRF (CEA)), Commissariat à l'énergie atomique et aux énergies alternatives (CEA)-Commissariat à l'énergie atomique et aux énergies alternatives (CEA)-Direction de Recherche Fondamentale (CEA) (DRF (CEA)), Commissariat à l'énergie atomique et aux énergies alternatives (CEA)-Commissariat à l'énergie atomique et aux énergies alternatives (CEA), European Synchrotron Radiation Facility (ESRF), Università degli studi di Torino = University of Turin (UNITO), Department of Pathological Anatomy, ASL-TO1, Martini Hospital, via Tofane 71, 10154, Torino, Italy., Institut des Sciences de la Terre (ISTerre), Institut Français des Sciences et Technologies des Transports, de l'Aménagement et des Réseaux (IFSTTAR)-Institut national des sciences de l'Univers (INSU - CNRS)-Institut de recherche pour le développement [IRD] : UR219-Université Savoie Mont Blanc (USMB [Université de Savoie] [Université de Chambéry])-Centre National de la Recherche Scientifique (CNRS)-Université Grenoble Alpes [2016-2019] (UGA [2016-2019]), CNR Istituto di Geoscienze e Georisorse (IGG ), National Research Council of Italy | Consiglio Nazionale delle Ricerche (CNR), Consiglio Nazionale delle Ricerche [Roma] (CNR)-Consiglio Nazionale delle Ricerche [Roma] (CNR), Department of Earth Sciences, University of Torino, Università degli studi di Torino (UNITO), Centre for Studies on Asbestos and other Toxic Particulates 'G. Scansetti', University of Torino, via Pietro Giuria 9, 10125, Turin, Italy., Consiglio Nazionale delle Ricerche (CNR) |
| Rok vydání: | 2017 |
| Předmět: |
Male
0301 basic medicine asbestos bodies synchrotron radiation biomineralization Biopsy Asbestosis 010501 environmental sciences medicine.disease_cause Biomineralisation asbestos FERRUGINOUS BODIES MALIGNANT MESOTHELIOMA X-RAY-ABSORPTION IRON STORAGE FERRIHYDRITE [SDV.MHEP.PSR]Life Sciences [q-bio]/Human health and pathology/Pulmonology and respiratory tract 01 natural sciences Coating MESOTHELIOMA Lung Chemical composition Aged 80 and over Mineral Fibers Multidisciplinary biology Chemistry Calcinosis FERRUGINOUS BODIES CANCER [SDV.TOX]Life Sciences [q-bio]/Toxicology Female Iron Mineralogy engineering.material Article Asbestos 03 medical and health sciences Ferrihydrite Metals Heavy Occupational Exposure ASBESTOS medicine Humans 0105 earth and related environmental sciences Radiochemistry BIOMINERALIZATION medicine.disease Trace Elements Ferritin 030104 developmental biology Hemosiderin engineering biology.protein Biomineralization |
| Zdroj: | Scientific Reports Scientific Reports, 2017, 7 (44862), ⟨10.1038/srep44862⟩ Scientific Reports, Nature Publishing Group, 2017, 7 (44862), ⟨10.1038/srep44862⟩ 'Scientific Reports ', vol: 7, pages: 44862-1-44862-11 (2017) |
| ISSN: | 2045-2322 |
| Popis: | Once penetrated into the lungs of exposed people, asbestos induces an in vivo biomineralisation process that leads to the formation of a ferruginous coating embedding the fibres. The ensemble of the fibre and the coating is referred to as asbestos body and is believed to be responsible for the high toxicological outcome of asbestos. Lung tissue of two individuals subjected to prolonged occupational exposure to crocidolite asbestos was investigated using synchrotron radiation micro-probe tools. The distribution of K and of elements heavier than Fe (Zn, Cu, As, and Ba) in the asbestos bodies was observed for the first time. Elemental quantification, also reported for the first time, confirmed that the coating is highly enriched in Fe (~20% w/w), and x-ray absorption spectroscopy indicated that Fe is in the 3+ oxidation state and that it is present in the form of ferritin or hemosiderin. Comparison of the results obtained studying the asbestos bodies upon removing the biological tissue by chemical digestion and those embedded in histological sections, allowed unambiguously distinguishing the composition of the asbestos bodies, and understanding to what extent the digestion procedure altered their chemical composition. A speculative model is proposed to explain the observed distribution of Fe. |
| Databáze: | OpenAIRE |
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