Human herpesvirus 7: antigenic properties and prevalence in children and adults
| Autor: | N Balachandran, Linda S. Wyatt, W J Rodriguez, Niza Frenkel |
|---|---|
| Rok vydání: | 1991 |
| Předmět: |
Adult
medicine.drug_class Herpesvirus 6 Human T-Lymphocytes viruses Blotting Western Immunology Herpesvirus 7 Human Biology Antibodies Viral Monoclonal antibody medicine.disease_cause Microbiology Virus Herpesviridae Viral Proteins Immune system Antigen Virology Prevalence medicine Humans Seroconversion Child Antigens Viral Age Factors Antibodies Monoclonal Infant virus diseases Herpesviridae Infections biochemical phenomena metabolism and nutrition Child Preschool Insect Science CD4 Antigens Humoral immunity biology.protein Antibody Research Article |
| Zdroj: | Journal of Virology. 65:6260-6265 |
| ISSN: | 1098-5514 0022-538X |
| Popis: | The recent isolation of human herpesvirus 7 (HHV-7) from activated CD4+ T lymphocytes of a healthy individual raises questions regarding the prevalence of this virus in humans and its immunological relationship to previously characterized human herpesviruses. We report that HHV-7 is a ubiquitous virus which is immunologically distinct from the highly prevalent T-lymphotropic HHV-6. Thus, (i) only two of six monoclonal antibodies to HHV-6 cross-reacted with HHV-7-infected cells, (ii) Western immunoblot analyses of viral proteins revealed different patterns for HHV-6- and HHV-7-infected cells, (iii) tests of sequential serum samples from children revealed seroconversion to HHV-6 without concomitant seroconversion to HHV-7, and (iv) in some instances HHV-7 infection occurred in the presence of high titers of HHV-6 antibodies, suggesting the lack of apparent protection of children seropositive for HHV-6 against subsequent infection with HHV-7. On the basis of the analyses of sera from children and adults it can be concluded that HHV-7 is a prevalent human herpesvirus which, like other human herpesviruses, infects during childhood. The age of infection appears to be somewhat later than the very early age documented for HHV-6. |
| Databáze: | OpenAIRE |
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