In vivo Elimination of Clonidine by Continuous Venovenous Hemofiltration in Critically Ill Patients
| Autor: | Polina Nassikovker, Fred A L van Steveninck, Huub L.A. van den Oever, M. Arbouw, Carmen M.A. Bles, Arriette Kruisdijk-Gerritsen, Marieke Zeeman, Arthur R. de Meijer |
|---|---|
| Rok vydání: | 2020 |
| Předmět: |
Adult
Male Continuous Renal Replacement Therapy Metabolic Clearance Rate Critical Illness medicine.medical_treatment Sedation Clonidine law.invention In vivo law Hemofiltration Sieving coefficient Humans Medicine business.industry Critically ill Hematology General Medicine Middle Aged Intensive care unit Continuous venovenous hemofiltration Nephrology Anesthesia Female medicine.symptom business medicine.drug |
| Zdroj: | Blood Purification. 49:622-626 |
| ISSN: | 1421-9735 0253-5068 |
| DOI: | 10.1159/000505610 |
| Popis: | Background: Clonidine is an α2-agonist that is commonly used for sedation in the intensive care unit. When patients are on continuous venovenous hemofiltration (CVVH) in the presence of kidney dysfunction, the sieving coefficient of clonidine is required to estimate how much drug is removed by CVVH. In the present study, we measured the sieving coefficient of clonidine in critically ill, ventilated patients receiving CVVH. Methods: A total of 20 samples of plasma and ultrafiltrate of 3 patients on CVVH, using a standard 1.5 m2 polyacrylonitrile AN69 membrane, during continuous clonidine infusion were collected. After correction for the effect of predilution, we calculated the sieving coefficient for clonidine. Results: The mean sieving coefficient of clonidine was 0.52 (SD 0.097). Conclusion: Using a polyacrylonitrile AN69 membrane in a CVVH machine, the in vivo sieving coefficient of clonidine was 0.52. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
|
| Nepřihlášeným uživatelům se plný text nezobrazuje | K zobrazení výsledku je třeba se přihlásit. |