Screening of children with hemihypertrophy, aniridia, and Beckwith-Wiedemann syndrome in patients with Wilms tumor: a report from the National Wilms Tumor Study
| Autor: | Pat A. Norkool, Daniel M. Green, Norman E. Breslow, J. B. Beckwith |
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| Rok vydání: | 1993 |
| Předmět: |
Male
congenital hereditary and neonatal diseases and abnormalities Cancer Research medicine.medical_specialty Pediatrics Beckwith-Wiedemann Syndrome Adolescent Beckwith–Wiedemann syndrome Asymptomatic Wilms Tumor Macroglossia Cryptorchidism medicine Humans Registries Stage (cooking) Prospective cohort study Child Hemihypertrophy Survival rate Aniridia Hip Dislocation Congenital Hypospadias business.industry Infant Wilms' tumor Hypertrophy medicine.disease Kidney Neoplasms Surgery Radiography Oncology Child Preschool Pediatrics Perinatology and Child Health Female medicine.symptom business |
| Zdroj: | Medical and pediatric oncology. 21(3) |
| ISSN: | 0098-1532 |
| Popis: | To evaluate the usefulness of regular radiographic screening to detect an asymptomatic intraabdominal tumor in patients with an increased risk of developing Wilms tumor, we reviewed the files of patients with hemihypertrophy, aniridia, or Beckwith-Wiedemann syndrome who were registered on the National Wilms Tumor Studies. Screening was employed infrequently in the management of children with hemihypertrophy, with only 25% (6/24) of those whose hemihypertrophy was identified more than 30 days prior to the diagnosis of Wilms tumor undergoing such examinations. Most patients with aniridia were evaluated regularly for the occcurrence of Wilms tumor. There were more stage 1 tumors identified in patients whose tumor was detected only through radiographic evaluation. The role of routine radiographic screening needs to be carefully evaluated in a homogeneous group of patients such as those with aniridia using a prospective study design to determine if such screening improves the survival rate of children with this rapidly growing, but readily treatable form of childhood cancer. © 1993 Wiley-Liss, Inc. |
| Databáze: | OpenAIRE |
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