Pilot Randomized Controlled Trial of a Standard Versus a Modified Low-Phosphorus Diet in Hemodialysis Patients
| Autor: | Orla Slevin, Oonagh N. Smith, Halóg Mellett, Fiona M. Keohane, Sarah Wade, Maria Bowles, Joyce Earlie, David W.P. Lappin, Donal N. Reddan, John Holian, Bernice L. Moore, Darren Dahly, Peter J. Conlon, Frances Shiely, Mairead Kiely, Alan J. Watson, Karina M. Brennan, Barbara Gillman, Liam F. Casserly, Denise C. McCarthy, Theresa Rennick, Yvonne M. O'Meara, George Mellotte, Fiona Byrne, Kieran Hannan, Eoin Bergin, Brendan A. Palmer, Patricia M. Kearney, Pauline Connolly, Celene M. Sands, Joseph A. Eustace |
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| Rok vydání: | 2020 |
| Předmět: |
medicine.medical_treatment
030232 urology & nephrology chemistry.chemical_element 030204 cardiovascular system & hematology Low phosphorus diet law.invention 03 medical and health sciences chemistry.chemical_compound Hyperphosphatemia 0302 clinical medicine Animal science Randomized controlled trial law Food choice medicine business.industry Phosphorus food and beverages Phosphate medicine.disease chemistry Tolerability Nephrology Commentary Hemodialysis business |
| Zdroj: | Kidney International Reports |
| ISSN: | 2468-0249 |
| DOI: | 10.1016/j.ekir.2020.08.008 |
| Popis: | Introduction The standard low-phosphorus diet restricts pulses, nuts, and whole grains and other high phosphorus foods to control hyperphosphatemia. We conducted a randomized controlled trial to evaluate the effectiveness, safety, and tolerability of the modified diet, which introduced some pulses and nuts, increased the use of whole grains, increased focus on the avoidance of phosphate additives, and introduced the prescription of low-biological-value protein such as bread. Methods We conducted a multicenter, pragmatic, parallel-arm, open-label, randomized controlled trial of modified versus standard diet in 74 adults on hemodialysis with hyperphosphatemia over 1 month. Biochemistry was assessed using monthly laboratory tests. Dietary intake was assessed using a 2-day record of weighed intake of food, and tolerability was assessed using a patient questionnaire. Results There was no significant difference in the change in serum phosphate between the standard and modified diets. Although total dietary phosphorus intake was similar, phytate-bound phosphorus, found in pulses, nuts, and whole grains, was significantly higher in the modified diet (P Conclusion The modified low phosphorus diet was well tolerated and was associated with similar phosphate and potassium control but with a wider food choice and greater fiber intake than the standard diet. |
| Databáze: | OpenAIRE |
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