Toward intelligent nanosize bioreactors: a pH-switchable, channel-equipped, functional polymer nanocontainer
| Autor: | Patrick Hunziker, Nadav Ben-Haim, Wolfgang Meier, Stephan Marsch, Joerg Ziegler, Sergey Driamov, Pavel Broz |
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| Rok vydání: | 2006 |
| Předmět: |
chemistry.chemical_classification
Nanostructure Chemistry Polymers Mechanical Engineering Analytical chemistry Substrate (chemistry) Nanocontainer Porins Bioengineering Nanotechnology General Chemistry Nanoreactor Polymer Biosensing Techniques Equipment Design Hydrogen-Ion Concentration Condensed Matter Physics Equipment Failure Analysis Membrane Bioreactors Copolymer General Materials Science Macromolecule |
| Zdroj: | Nano letters. 6(10) |
| ISSN: | 1530-6984 |
| Popis: | To develop an intelligent sensor-effector functionality on the nanoscale, a pH-switchable, controlled nanoreactor based on amphiphilic copolymer membranes was built. The nanovesicles were equipped with bacterial transmembrane ompF pore proteins and the pH-sensitive enzyme acid phosphatase, resulting in a switchable substrate processing at pH 4-6.5. Ideal pH and substrate concentrations for the reaction were determined experimentally. In future, the reactor might be used for self-regulating targeted diagnostic and therapeutic applications in medicine. |
| Databáze: | OpenAIRE |
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