Molecular insight into targeting the NK cell immune response to cancer
Autor: | Melissa J. Davis, Fernando Souza-Fonseca-Guimaraes, Nicholas D. Huntington, Rebecca B. Delconte, Soroor Hediyeh-Zadeh, Jai Rautela |
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Rok vydání: | 2018 |
Předmět: |
Cytotoxicity
Immunologic 0301 basic medicine medicine.medical_treatment Cellular differentiation Immunology Biology Natural killer cell 03 medical and health sciences Immune system Cancer immunotherapy Neoplasms Tumor Microenvironment medicine Animals Homeostasis Humans Immunology and Allergy Immunologic Surveillance Tumor microenvironment Cancer Cell Differentiation Cell Biology Immunotherapy medicine.disease Killer Cells Natural 030104 developmental biology medicine.anatomical_structure Cancer cell Cancer research |
Zdroj: | Immunology and Cell Biology. 96:477-484 |
ISSN: | 0818-9641 |
Popis: | Natural Killer (NK) cells have long been considered an important part of the anti-tumor immune response due to their potent cytolytic and cytokine-secreting abilities. To date, a clear demonstration of the role NK cells play in human cancer is lacking, and there are still very few examples of therapies that efficiently exploit or enhance the spontaneous ability of NK cells to destroy the autologous cancer cells. Given the paradigm shift toward cancer immunotherapy over the past decade, there is a renewed push to understand how NK cell homeostasis and function are regulated in order to therapeutically harness these cells to treat cancer. This review will highlight recent advancements in our understanding of how growth factors impact on NK cell development, differentiation, survival and function with an emphasis on how these pathways may influence NK cell activity in the tumor microenvironment and control of cancer metastasis. |
Databáze: | OpenAIRE |
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