Deep Penetration of Nanolevel Drugs and Micrometer-Level T Cells Promoted by Nanomotors for Cancer Immunochemotherapy
| Autor: | Zhiyong Liu, Xingwen Wang, Huan Chen, Huanyu Zhang, Tao Shi, Baorui Liu, Mimi Wan, Chun Mao, Zhuoyue Miao, Yue Wang, Jia Wei, Fangcen Liu |
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| Rok vydání: | 2021 |
| Předmět: |
T-Lymphocytes
medicine.medical_treatment Motility Breast Neoplasms Docetaxel Nitric Oxide Biochemistry Catalysis Nitric oxide Extracellular matrix Mice chemistry.chemical_compound Colloid and Surface Chemistry Immune system In vivo Tumor Microenvironment medicine Animals Humans Cell Proliferation Tumor microenvironment Chemistry Mammary Neoplasms Experimental food and beverages General Chemistry Immunotherapy medicine.disease Nanostructures Cell biology MCF-7 Cells Female Infiltration (medical) |
| Zdroj: | Journal of the American Chemical Society. 143:12025-12037 |
| ISSN: | 1520-5126 0002-7863 |
| DOI: | 10.1021/jacs.1c03071 |
| Popis: | The ability of nanomotors to promote the deep penetration of themselves and the loaded drugs in diseased tissues has been proposed and confirmed. However, whether such motion behavior of the nanomotors can also promote deep penetration of micrometer-sized immune cells in the diseased microenvironment, which is important for the immunotherapy of some diseases, has not been mentioned. Herein, we construct a nitric oxide (NO)-driven nanomotor that can move in the tumor microenvironment, focusing on its motion behavior and the role of NO, the beneficial product released during movement from this kind of nanomotor, in regulating the infiltration behavior and activity of immune cells. It can be found that the drug-loaded nanomotors with both NO-releasing ability and motility can promote the normalization of the tumor vasculature system and the degradation of the intrinsic extracellular matrix (ECM), which can significantly improve the tumor infiltration ability of T cells in vivo. The efficiency of T-cell infiltration in tumor tissue in vivo increased from 2.1 to 28.2%. Both subcutaneous and intraperitoneal implantation tumor models can validate the excellent antitumor effect of drug-loaded NO-driven nanomotors. This combination of motility of the power source from nanomotors and their physiological function offers a design idea for therapeutic agents for the future immunotherapy of many diseases. |
| Databáze: | OpenAIRE |
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