Pyrido[2,3-d]pyrimidin-7(8H)-ones: Synthesis and Biomedical Applications
| Autor: | Jordi Teixidó, Raimon Puig de la Bellacasa, José I. Borrell, Guillem Jubete, Roger Estrada-Tejedor |
|---|---|
| Jazyk: | angličtina |
| Rok vydání: | 2019 |
| Předmět: |
Pyrimidine
Stereochemistry 5 6-dihydropyrido[2 3-d]pyrimidin-7(8H)-ones Pharmaceutical Science biological activity Review Chemistry Techniques Synthetic Pyrimidinones Ring (chemistry) pyrido[2 3-d]pyrimidines 01 natural sciences Analytical Chemistry lcsh:QD241-441 03 medical and health sciences chemistry.chemical_compound Structure-Activity Relationship lcsh:Organic chemistry Drug Discovery Pyridine Physical and Theoretical Chemistry 030304 developmental biology 0303 health sciences Molecular Structure 010405 organic chemistry Chemistry Organic Chemistry substitution pattern 0104 chemical sciences Pyrimidines Chemistry (miscellaneous) Molecular Medicine 5 6-dihydropyrido[2 3-d]pyrimidin-7(8h)-ones |
| Zdroj: | Molecules, Vol 24, Iss 22, p 4161 (2019) Molecules |
| ISSN: | 1420-3049 |
| Popis: | Pyrido[2,3-d]pyrimidines (1) are a type of privileged heterocyclic scaffolds capable of providing ligands for several receptors in the body. Among such structures, our group and others have been particularly interested in pyrido[2,3-d]pyrimidine-7(8H)-ones (2) due to the similitude with nitrogen bases present in DNA and RNA. Currently there are more than 20,000 structures 2 described which correspond to around 2900 references (half of them being patents). Furthermore, the number of references containing compounds of general structure 2 have increased almost exponentially in the last 10 years. The present review covers the synthetic methods used for the synthesis of pyrido[2,3-d]pyrimidine-7(8H)-ones (2), both starting from a preformed pyrimidine ring or a pyridine ring, and the biomedical applications of such compounds. |
| Databáze: | OpenAIRE |
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