Effects of phenolic acids on the growth and production of T‐2 and HT‐2 toxins by Fusarium langsethiae and F. sporotrichioides
| Autor: | Agustín Ariño, Florence Richard-Forget, Christian Barreau, Vessela Atanasova-Penichon, Gisèle Marchegay, Christine Ducos, Laetitia Pinson-Gadais, Marie-Noelle Bonnin-Verdal, Susana Lorán, Elena Ferruz |
|---|---|
| Přispěvatelé: | University of Zaragoza - Universidad de Zaragoza [Zaragoza], Unité de recherche Mycologie et Sécurité des Aliments (MycSA), Institut National de la Recherche Agronomique (INRA) |
| Jazyk: | angličtina |
| Rok vydání: | 2016 |
| Předmět: |
0301 basic medicine
[SDV]Life Sciences [q-bio] Pharmaceutical Science fusarium sporotrichioidese biosynthèse Analytical Chemistry Ferulic acid chemistry.chemical_compound Fusarium Gene Expression Regulation Fungal Drug Discovery Caffeic acid Hydroxybenzoates Fungal protein biology phenolic acid Fusarium sporotrichioides acide phénolique T-2 Toxin Biochemistry Chemistry (miscellaneous) acide chlorogénique Molecular Medicine Chlorogenic Acid mycotoxine Coumaric Acids 030106 microbiology trichothecene Article Fusarium langsethiae type A trichothecene Tri gene Fungal Proteins lcsh:QD241-441 03 medical and health sciences Caffeic Acids Chlorogenic acid lcsh:Organic chemistry tri gene fusarium langsethiae biomasse fongique Physical and Theoretical Chemistry Mycotoxin Organic Chemistry Phenolic acid biology.organism_classification 030104 developmental biology chemistry acide férulique Propionates |
| Zdroj: | Molecules Molecules, MDPI, 2016, 21 (4), 11 p. ⟨10.3390/molecules21040449⟩ Molecules, Vol 21, Iss 4, p 449 (2016) Zaguán. Repositorio Digital de la Universidad de Zaragoza instname Molecules; Volume 21; Issue 4; Pages: 449 Molecules 4 (21), 11 p.. (2016) |
| ISSN: | 1420-3049 |
| Popis: | International audience; The effect of natural phenolic acids was tested on the growth and production of T‐2 and HT‐2 toxins by Fusarium langsethiae and F. sporotrichioides, on Mycotoxin Synthetic medium. Plates treated with 0.5 mM of each phenolic acid (caffeic, chlorogenic, ferulic and p‐coumaric) and controls without phenolic acid were incubated for 14 days at 25 °C. Fungal biomass of F. langsethiae and F. sporotrichioides was not reduced by the phenolic acids. However, biosynthesis of T‐2 toxin by F. langsethiae was significantly reduced by chlorogenic (23.1%) and ferulic (26.5%) acids. Production of T‐2 by F. sporotrichioides also decreased with ferulic acid by 23% (p < 0.05). In contrast, p‐coumaric acid significantly stimulated the production of T‐2 and HT‐2 toxins for both strains. A kinetic study of F. langsethiae with 1 mM ferulic acid showed a significant decrease in fungal biomass, whereas T‐2 production increased after 10 days of incubation. The study of gene expression in ferulic supplemented cultures of F. langsethiae revealed a significant inhibition for Tri5, Tri6 and Tri12 genes, while for Tri16 the decrease in gene expression was not statistically significant. Overall, results indicated that phenolic acids had a variable effect on fungal growth and mycotoxin production, depending on the strain and the concentration and type of phenolic acid assayed. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
|