A conserved neuropeptide system links head and body motor circuits to enable adaptive behavior
| Autor: | Liliane Schoofs, Isabel Beets, Denis Touroutine, Christopher M. Lambert, Kellianne Alexander, Navonil Banerjee, Shankar Ramachandran, Jeremy Florman, Raja Bhattacharya, Michael M. Francis, Mark J. Alkema, Michele L. Lemons |
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| Rok vydání: | 2021 |
| Předmět: |
Motor circuit
Nervous system QH301-705.5 Head (linguistics) Science local search Neuropeptide Stimulation Biology General Biochemistry Genetics and Molecular Biology Receptors G-Protein-Coupled 03 medical and health sciences 0302 clinical medicine Adaptation Psychological Biological neural network medicine Animals G protein-coupled receptor Biology (General) Caenorhabditis elegans Caenorhabditis elegans Proteins neuropeptide neural circuits Cholecystokinin 030304 developmental biology Adaptive behavior 0303 health sciences General Immunology and Microbiology General Neuroscience Neuropeptides General Medicine Motor neuron biology.organism_classification cholecystokinin medicine.anatomical_structure C. elegans Medicine Neuron Neuroscience 030217 neurology & neurosurgery Locomotion Research Article |
| Zdroj: | eLife eLife, Vol 10 (2021) |
| ISSN: | 2050-084X |
| Popis: | SUMMARYNeuromodulators promote adaptive behaviors that are often complex and involve concerted activity changes across circuits that are often not physically connected. It is not well understood how neuromodulatory systems accomplish these tasks. Here we show that the C. elegans NLP-12 neuropeptide system shapes responses to food availability by modulating the activity of head and body wall motor neurons through alternate G-protein coupled receptor (GPCR) targets, CKR-1 and CKR-2. We show ckr-2 deletion reduces body bend depth during movement under basal conditions. We demonstrate CKR-1 is a functional NLP-12 receptor and define its expression in the nervous system. In contrast to basal locomotion, biased CKR-1 GPCR stimulation of head motor neurons promotes turning during local searching. Deletion of ckr-1 reduces head neuron activity and diminishes turning while specific ckr-1 overexpression or head neuron activation promote turning. Thus, our studies suggest locomotor responses to changing food availability are regulated through conditional NLP-12 stimulation of head or body wall motor circuits.Impact statementInvestigation of neuromodulatory control of ethologically conserved area-restricted food search behavior shows that NLP-12 stimulation of the head motor circuit promotes food searching through the previously uncharacterized CKR-1 GPCR. |
| Databáze: | OpenAIRE |
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