Gold-Catalyzed Intramolecular Regioselective 7-exo-dig Cyclization To Access 3-Methylene-3,4-dihydrobenzo[b]oxepinones
| Autor: | Galla V. Karunakar, Kommuru Goutham, B. Sridhar, Veerabhushanam Kadiyala, Ravinder Guduru, N. S. V. M. Rao Mangina |
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| Rok vydání: | 2016 |
| Předmět: |
010405 organic chemistry
Chemistry Aryl Organic Chemistry Regioselectivity Bond formation 010402 general chemistry 01 natural sciences Biochemistry Medicinal chemistry 0104 chemical sciences Catalysis chemistry.chemical_compound Intramolecular force Dig Organic chemistry Physical and Theoretical Chemistry Methylene |
| Zdroj: | Organic Letters. 19:282-285 |
| ISSN: | 1523-7052 1523-7060 |
| DOI: | 10.1021/acs.orglett.6b03433 |
| Popis: | An efficient gold-catalyzed synthesis of substituted 3-methylene-3,4-dihydrobenzo[b]oxepinones from ortho-O-propargyl substituted aryl enaminones has been achieved. In this transformation a new C-C bond formation occurred regioselectively via 7-exo-dig cyclization. Benzooxepinone derivatives were obtained in good to excellent yields in a one-pot synthesis at ambient temperature. |
| Databáze: | OpenAIRE |
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