Argentinean recommendations on the identification of treatment failure in relapsing remitting multiple sclerosis patients
| Autor: | Ramiro Linares, Amelia Alvez Pinheiro, N. Deri, Diego Giunta, Marcos Burgos, Jorge Correale, Geraldine Luetic, Miguel Jacobo, Edgardo Cristiano, Ricardo Alonso, Andres Villa, Eduardo Kohler, María C. Ysrraelit, Liliana Patrucco, Roberto Rotta Escalante, Adriana Carrá, Ernesto Crespo, Nora Fernández Liguori, Santiago A. Vétere, Mario Javier Halfon, Jorge Fernandez, Juan Ignacio Rojas, María Celeste Curbelo, Edgar Carnero Contentti, Carlos Vrech, Raúl Piedrabuena, Jimena Miguez, Berenice Silva, Maria Laura Saladino, María Eugenia Balbuena, María I. Gaitán, Orlando Garcea, Santiago Bestoso, Vladimiro Sinay, Elizabeth A. Bacile, Pedro Nofal, Andrés Barboza, Adriana Tarulla, Javier Pablo Hryb, Fernando Caceres, Alejandra D. Martinez, Carlos Ballario, Judith Steinberg, Marcela Fiol |
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| Rok vydání: | 2017 |
| Předmět: |
medicine.medical_specialty
Neurology Consensus Argentina Treatment failure 03 medical and health sciences Disability Evaluation 0302 clinical medicine Multiple Sclerosis Relapsing-Remitting Health care Medicine Humans 030212 general & internal medicine Treatment Failure Disease management (health) Intensive care medicine business.industry Multiple sclerosis Guideline medicine.disease Identification (information) Relapsing remitting Neurology (clinical) business 030217 neurology & neurosurgery |
| Zdroj: | Journal of the neurological sciences. 385 |
| ISSN: | 1878-5883 |
| Popis: | One of the biggest challenges in multiple sclerosis (MS) is the definition of treatment response/failure in order to optimize treatment decisions in affected patients. The objective of this consensus was to review how disease activity should be assessed and to propose recommendations on the identification of treatment failure in RRMS patients in Argentina. Methods A panel of experts in neurology from Argentina, dedicated to the diagnosis and care of MS patients, gathered both virtually and in person during 2016 and 2017 to carry out a consensus recommendation on the identification of treatment failure in RRMS patients. To achieve consensus, the methodology of “formal consensus-RAND/UCLA method” was used. Results Recommendations were established based on published evidence and the expert opinion. Recommendations focused on disease management, disease activity markers and treatment failure identification were determined. Main consensus were: ≥ 2 relapses during the first year of treatment and/or ≥ 3 new or enlarged T2 or T1 GAD + lesions and/or sustained increase of ≥ 2 points in EDSS or ≥ 100% in T25FW defines treatment failure in RRMS patients. Conclusions The recommendations of this consensus guidelines attempts to optimize the health care and management of patients with MS in Argentina. |
| Databáze: | OpenAIRE |
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