Recognition of concanavalin a by cationic glucosylated liposomes
| Autor: | Giovanna Mancini, Alessandro Mauceri, Livia Salvati Manni, Luisa Giansanti, Luciano Galantini, Antonio Di Martino, Stefano Borocci, Claudio Sperduto |
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| Jazyk: | angličtina |
| Rok vydání: | 2014 |
| Předmět: |
Models
Molecular Glycosylation Phospholipid macromolecular substances chemistry.chemical_compound Surface-Active Agents Models Cations Amphiphile Concanavalin A Electrochemistry General Materials Science Spectroscopy Liposome biology Molecular Structure Chemistry Liposomes Condensed Matter Physics Surfaces and Interfaces Materials Science (all) Medicine (all) Cationic polymerization Lectin Molecular Agglutination (biology) Drug delivery biology.protein Biophysics |
| Zdroj: | Langmuir (Online) 30 (2014): 11301–11306. doi:10.1021/la502946t info:cnr-pdr/source/autori:A. Mauceri, S. Borocci, L. Galantini, L. Giansanti, G. Mancini, A. Martino, L. Salvati Manni, C. Sperduto/titolo:Recognition of concanavalin a by cationic glucosylated liposomes/doi:10.1021%2Fla502946t/rivista:Langmuir (Online)/anno:2014/pagina_da:11301/pagina_a:11306/intervallo_pagine:11301–11306/volume:30 |
| Popis: | The specificity of carbohydrate-lectin interaction has been reported as an attractive strategy for drug delivery in cancer therapy because of the high levels of lectins in several human malignancies. A novel cationic glucosylated amphiphile was therefore synthesized, as a model system, to attribute specificity toward d-glucose receptors to liposome formulations. Fluorescence experiments demonstrated that the monomeric glucosylated amphiphile is capable of interacting with fluorescently labeled concanavalin A, a d-glucose specific plant lectin. The interaction of concanavalin A with liposomes composed of a phospholipid and the glucosylated amphiphile was demonstrated by agglutination observed by optical density and dynamic laser light scattering measurements, thus paving the way to the preparation of other glycosilated amphiphiles differing for the length of polyoxyethylenic spacer, the sugar moieties, and/or the length of the hydrophobic chain. |
| Databáze: | OpenAIRE |
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