Antiplatelet Effects of Nitroglycerin in Healthy Subjects and in Patients with Stable Angina Pectoris
| Autor: | Jurate I. Naujalis, R. E. Sage, Yuliy Y. Chirkov, John D. Horowitz |
|---|---|
| Rok vydání: | 1993 |
| Předmět: |
Adult
Blood Platelets Male medicine.medical_specialty genetic structures Endogeny In Vitro Techniques Angina Pectoris Sublingual administration Nitric oxide Angina Nitroglycerin chemistry.chemical_compound In vivo Internal medicine medicine Humans Platelet In patient Cyclic GMP Aged Pharmacology business.industry Middle Aged medicine.disease eye diseases Adenosine Diphosphate chemistry Cardiology Female sense organs Cardiology and Cardiovascular Medicine business Platelet Aggregation Inhibitors medicine.drug |
| Zdroj: | Journal of Cardiovascular Pharmacology. 21:384-389 |
| ISSN: | 0160-2446 |
| DOI: | 10.1097/00005344-199303000-00006 |
| Popis: | The effects of nitroglycerin (NTG) on platelet aggregation are controversial. Most in vitro investigations suggest that NTG suppresses platelet aggregation only at suprapharmacologic concentrations. We investigated various aspects of the antiaggregating effects of NTG in both normal individuals and in patients with stable angina pectoris not treated with nitrates. Platelets from patients exhibited hyperresponsiveness to ADP as an inductor of aggregation. Sublingual administration to patients of NTG (300 micrograms) decreased platelet aggregability; ADP concentrations inducing 50% aggregation were 3.3 +/- 0.3 microM after NTG versus 2.1 +/- 0.1 microM before NTG (p0.01). Consistent with previous findings, NTG was a weak inhibitor of platelet aggregation in vitro when added before induction of aggregation. When added after the beginning of aggregation, however, NTG induced both inhibition of developing aggregation and marked disaggregation at concentrationsor = 10(-8) M NTG; concentration associated with 50% reversal of aggregation was 1.4 +/- 0.3 x 10(-6) M. Therefore, antiplatelet effects of NTG in vitro are demonstrable in low, clinically achievable concentrations; previously reported effects of NTG have been underestimated owing to suboptimum experimental conditions. Platelets from patients with angina pectoris were 100-fold less responsive to the cyclic GMP-increasing and disaggregating effects of NTG in vitro, which, together with increased aggregability, could imply reduced platelet sensitivity to endogenous sources of nitric oxide (NO) in vivo. The observed antiplatelet effects of NTG raise the question of its potential utility to reduce the risk of thrombotic complications in patients with ischemic heart disease. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
|