Elimination studies of antipyrine and its metabolites in healthy Saudi Arabians
| Autor: | Jens O. Sieck, Dale A. Raines, Martin Døssing, Jalal Saour, Adnan El-Yazigi, Hatim Ali, Peter Ernst |
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| Rok vydání: | 1994 |
| Předmět: |
Oral dose
Adult Male medicine.medical_specialty Adolescent Metabolic Clearance Rate Health Toxicology and Mutagenesis Saudi Arabia Administration Oral Black People Pharmacology Toxicology Body weight 030226 pharmacology & pharmacy White People 03 medical and health sciences 0302 clinical medicine Urinary excretion Pharmacokinetics Asian People Internal medicine Metabolic clearance rate Edaravone medicine Humans 030212 general & internal medicine 3-hydroxymethylantipyrine Chromatography High Pressure Liquid Age differences business.industry General Medicine Endocrinology Multicenter study Female business Antipyrine |
| Zdroj: | Humanexperimental toxicology. 13(10) |
| ISSN: | 0960-3271 |
| Popis: | 1 We measured the antipyrine clearance in 18 healthy Saudi subjects and determined the urinary excretion of three of its metabolites: 4-hydroxyantipyrine (4-OH AP), norantipyrine (NOR AP) and 3 hydroxymethylantipyrine (3-OHM AP) in 21 subjects. 2 The mean ± SD of the antipyrine clearance was 2.4 ± 1.1 h-1 (range 1.0-5.5 l h-1) and the corresponding value per kg body weight was 0.6 ± 0.2 ml min-1 kg-1. Urinary excretion of antipyrine (AP), 4-OH AP, NOR AP and 3-OHM AP expressed as a percentage of the oral dose of antipyrine given was 2.8 ± 2.2, 14.5 ± 6.9, 12.3 ± 5.6 and 7.6 ± 3.2 respectively. 3 Compared to Africans, Saudis preferentially metabolize AP to NOR AP and compared to Caucasians to 3-OHM AP, rather than to 4-OH AP. These discrepancies may reflect age differences between the study populations rather than genetic or ethnic variations. |
| Databáze: | OpenAIRE |
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