Long non-coding RNA CASC2 regulates cell biological behaviour through the MAPK signalling pathway in hepatocellular carcinoma
Autor: | Mei-Xia Zhang, Zhi-Xiong Long, Ximing Xu, Yuan-Yuan Gan, Na-Na Han, Yongfa Zheng, Wei Ge, Jun-Jian Deng, Xiaoqin He, Yujie Zhou, Huiling Liang, Jia-Jun Yu |
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Jazyk: | angličtina |
Rok vydání: | 2017 |
Předmět: |
Adult
Male 0301 basic medicine Carcinoma Hepatocellular Carcinogenesis MAP Kinase Signaling System Cell Biology 03 medical and health sciences 0302 clinical medicine Cell Movement medicine Humans Genes Tumor Suppressor Protein kinase A RC254-282 Aged Cell Proliferation Tumor Suppressor Proteins Liver Neoplasms RNA Cancer Neoplasms. Tumors. Oncology. Including cancer and carcinogens Hep G2 Cells General Medicine Middle Aged medicine.disease Hedgehog signaling pathway Long non-coding RNA Gene Expression Regulation Neoplastic 030104 developmental biology medicine.anatomical_structure Apoptosis 030220 oncology & carcinogenesis Hepatocellular carcinoma Cancer research Female RNA Long Noncoding |
Zdroj: | Tumor Biology, Vol 39 (2017) |
ISSN: | 1423-0380 |
Popis: | Long non-coding RNAs have previously been demonstrated to play important roles in regulating human diseases, especially cancer. However, the biological functions and molecular mechanisms of long non-coding RNAs in hepatocellular carcinoma have not been extensively studied. The long non-coding RNA CASC2 (cancer susceptibility candidate 2) has been characterised as a tumour suppressor in endometrial cancer and gliomas. However, the role and function of CASC2 in hepatocellular carcinoma remain unknown. In this study, using quantitative real-time polymerase chain reaction, we confirmed that CASC2 expression was downregulated in 50 hepatocellular carcinoma cases (62%) and in hepatocellular carcinoma cell lines compared with the paired adjacent tissues and normal liver cells. In vitro experiments further demonstrated that overexpressed CASC2 decreased hepatocellular carcinoma cell proliferation, migration and invasion as well as promoted apoptosis via inactivating the mitogen-activated protein kinase signalling pathway. Our findings demonstrate that CASC2 could be a useful tumour suppressor factor and a promising therapeutic target for hepatocellular carcinoma. |
Databáze: | OpenAIRE |
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