Comprehensive profiling of the gut microbiota in patients with chronic obstructive pulmonary disease of varying severity
| Autor: | Tzuo-Yun Lan, Rebecca Chou-Jui Lin, Chi Wei Liu, Shih-Wei Lee, Yu-Chi Chiu, Lawrence Shih-Hsin Wu, Yung-Chia Huang |
|---|---|
| Jazyk: | angličtina |
| Rok vydání: | 2021 |
| Předmět: |
0301 basic medicine
Male Pulmonology Pulmonary Function Gut flora Pathology and Laboratory Medicine Severity of Illness Index Pulmonary function testing White Blood Cells Feces Pulmonary Disease Chronic Obstructive 0302 clinical medicine Medical Conditions Animal Cells RNA Ribosomal 16S Medicine and Health Sciences Bacteroides Respiratory function Aged 80 and over COPD Clostridiales Multidisciplinary biology Respiratory disease Genomics Fusobacterium Middle Aged Bacterial Pathogens medicine.anatomical_structure Medical Microbiology Medicine Cellular Types Pathogens Research Article Chronic Obstructive Pulmonary Disease Immune Cells Inflammatory Diseases Science Immunology Microbial Genomics Microbiology digestive system 03 medical and health sciences medicine Genetics Humans Microbiome Microbial Pathogens Aged Lung Blood Cells Bacteria business.industry Gut Bacteria Organisms Biology and Life Sciences Cell Biology medicine.disease biology.organism_classification Gastrointestinal Microbiome respiratory tract diseases Eosinophils 030104 developmental biology 030228 respiratory system Respiratory failure business |
| Zdroj: | PLoS ONE, Vol 16, Iss 4, p e0249944 (2021) PLoS ONE |
| ISSN: | 1932-6203 |
| Popis: | Chronic obstructive pulmonary disease (COPD) is a chronic respiratory disease that reduces lung and respiratory function, with a high mortality rate. Severe and acute deterioration of COPD can easily lead to respiratory failure, resulting in personal, social, and medical burden. Recent studies have shown a high correlation between the gut microbiota and lung inflammation. In this study, we investigated the relationship between gut microbiota and COPD severity. A total of 60 COPD patients with varying severity according to GOLD guidelines were enrolled in this study. DNA was extracted from patients’ stool and 16S rRNA data analysis conducted using high-throughput sequencing followed by bioinformatics analysis. The richness of the gut microbiota was not associated with COPD severity. The gut microbiome is more similar in stage 1 and 2 COPD than stage 3+4 COPD.FusobacteriumandAerococcuswere more abundant in stage 3+4 COPD. Ruminococcaceae NK4A214 group andLachnoclostridiumwere less abundant in stage 2–4, andTyzzerella 4andDialisterwere less abundant in stage 1. However, the abundance of aBacteroideswas associated with blood eosinophils and lung function. This study suggests that no distinctive gut microbiota pattern is associated with the severity of COPD. The gut microbiome could affect COPD by gut inflammation shaping the host immune system. |
| Databáze: | OpenAIRE |
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