House dust mites activate nociceptor–mast cell clusters to drive type 2 skin inflammation
| Autor: | Mindy Tsai, Camille Petitfils, Nicolas Cenac, Stephen J. Galli, Riccardo Sibilano, Xinzhong Dong, Laurent L. Reber, Nicolas Gaudenzio, Lilian Basso, Philipp Starkl, Nadine Serhan, Chrystelle Bonnart, Thomas Marichal, James Meixiong |
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| Přispěvatelé: | Institut National de la Santé et de la Recherche Médicale (INSERM), Stanford University School of Medicine [CA, USA], Institut de Recherche en Santé Digestive (IRSD ), Université Toulouse III - Paul Sabatier (UT3), Université Fédérale Toulouse Midi-Pyrénées-Université Fédérale Toulouse Midi-Pyrénées-Institut National de la Recherche Agronomique (INRA)-Ecole Nationale Vétérinaire de Toulouse (ENVT), Institut National Polytechnique (Toulouse) (Toulouse INP), Université Fédérale Toulouse Midi-Pyrénées-Université Fédérale Toulouse Midi-Pyrénées-Institut National Polytechnique (Toulouse) (Toulouse INP), Université Fédérale Toulouse Midi-Pyrénées-Institut National de la Santé et de la Recherche Médicale (INSERM), Johns Hopkins University, School of Medicine, Centre de Physiopathologie Toulouse Purpan (CPTP), Université Fédérale Toulouse Midi-Pyrénées-Université Fédérale Toulouse Midi-Pyrénées-Institut National de la Santé et de la Recherche Médicale (INSERM)-Centre National de la Recherche Scientifique (CNRS), Université de Liège, Walloon Excellence in Life sciences and BIOtechnology [Liège] (WELBIO), Research Center for Molecular Medicine of the Austrian Academy of Sciences, Medizinische Universität Wien = Medical University of Vienna, the Stanford Neuroscience Microscopy Service (supported by NIH No. NS069375), (IFR30, Plateau Technique Cytometrie, Toulouse), (IFR30, Plateau Technique Imagerie Cellulaire, Toulouse), ‘Incentive Grant for Scientific Research’ of the F.R.S.-FNRS (No. F.4508.18), by the FRFS-WELBIO under grant No. CR-2017 s-04, by the Acteria Foundation and by an ERC Starting Grant (No. IM-ID 801823), the Austrian Science Fund (No. P31113-B30), ProdInra, Migration, Institut National de la Recherche Agronomique (INRA)-Université Toulouse III - Paul Sabatier (UT3), Université Fédérale Toulouse Midi-Pyrénées-Université Fédérale Toulouse Midi-Pyrénées-Ecole Nationale Vétérinaire de Toulouse (ENVT) |
| Rok vydání: | 2019 |
| Předmět: |
Male
0301 basic medicine [SDV.BIO]Life Sciences [q-bio]/Biotechnology MESH: Nociceptors / metabolism Dermatitis MESH: Skin / cytology Cell Communication MESH: Mast Cells / metabolism MESH: Tachykinins / genetics MESH: Dermatitis Atopic / pathology MESH: Mice Knockout Receptors G-Protein-Coupled Mice 0302 clinical medicine TAC1 Receptors 2.1 Biological and endogenous factors Immunology and Allergy Mast Cells Aetiology Acute inflammation Skin Mice Knockout MESH: Cell Communication / immunology Chemistry MESH: Dermatitis Atopic / immunology Pyroglyphidae Pain Research Degranulation Nociceptors Mast cell Research Highlight MESH: Mast Cells / immunology 3. Good health Nociception medicine.anatomical_structure Nociceptor MESH: Tachykinins / metabolism Female Chronic Pain medicine.symptom Cell signalling MESH: Skin / immunology Knockout Immunology TRPV1 TRPV Cation Channels Inflammation MESH: Nociceptors / immunology Article Atopic Dermatitis Atopic G-Protein-Coupled 03 medical and health sciences Tachykinins medicine Animals Humans MESH: Receptors G-Protein-Coupled / metabolism Animal Inflammatory and immune system Neurosciences MESH: Allergens / immunology MESH: TRPV Cation Channels / metabolism MESH: Pyroglyphidae / immunology Allergens [SDV.BIO] Life Sciences [q-bio]/Biotechnology [SDV.AEN] Life Sciences [q-bio]/Food and Nutrition Disease Models Animal 030104 developmental biology nervous system Disease Models Itching MESH: Disease Models Animal [SDV.AEN]Life Sciences [q-bio]/Food and Nutrition 030215 immunology |
| Zdroj: | Nature immunology, vol 20, iss 11 Nature Immunology Nature Immunology, Nature Publishing Group, 2019, 20 (11), pp.1435-1443. ⟨10.1038/s41590-019-0493-z⟩ Nature immunology Cellular and Molecular Immunology Nature Immunology, 2019, 20 (11), pp.1435-1443. ⟨10.1038/s41590-019-0493-z⟩ |
| ISSN: | 1529-2916 1529-2908 |
| DOI: | 10.1038/s41590-019-0493-z |
| Popis: | International audience; Allergic skin diseases, such as atopic dermatitis, are clinically characterized by severe itching and type 2 immunity-associated hypersensitivity to widely distributed allergens, including those derived from house dust mites (HDMs). Here we found that HDMs with cysteine protease activity directly activated peptidergic nociceptors, which are neuropeptide-producing nociceptive sensory neurons that express the ion channel TRPV1 and Tac1, the gene encoding the precursor for the neuropeptide substance P. Intravital imaging and genetic approaches indicated that HDM-activated nociceptors drive the development of allergic skin inflammation by inducing the degranulation of mast cells contiguous to such nociceptors, through the release of substance P and the activation of the cationic molecule receptor MRGPRB2 on mast cells. These data indicate that, after exposure to HDM allergens, activation of TRPV1+Tac1+ nociceptor–MRGPRB2+ mast cell sensory clusters represents a key early event in the development of allergic skin reactions. |
| Databáze: | OpenAIRE |
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