Control of Drosophila Gastrulation by Apical Localization of Adherens Junctions and RhoGEF2
| Autor: | Luis Serrano, Verena Kölsch, Maria Leptin, Thomas C. Seher, Gregorio Fernández-Ballester |
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| Rok vydání: | 2007 |
| Předmět: |
rho GTP-Binding Proteins
Mesoderm Cell signaling Embryo Nonmammalian animal structures Amino Acid Motifs Embryonic Development Ventral furrow formation Cell Cycle Proteins Biology Models Biological Adherens junction Twist transcription factor medicine Animals Drosophila Proteins Cell Shape Armadillo Domain Proteins Multidisciplinary Cell Membrane Twist-Related Protein 1 Membrane Proteins Apical constriction Adherens Junctions Gastrula Heterotrimeric GTP-Binding Proteins Cell biology Gastrulation Drosophila melanogaster medicine.anatomical_structure Drosophila Protein Signal Transduction Transcription Factors |
| Zdroj: | Science. 315:384-386 |
| ISSN: | 1095-9203 0036-8075 |
| DOI: | 10.1126/science.1134833 |
| Popis: | A hallmark of epithelial invagination is the constriction of cells on their apical sides. During Drosophila gastrulation, apical constrictions under the control of the transcription factor Twist lead to the invagination of the mesoderm. Twist-controlled G protein signaling is involved in mediating the invagination but is not sufficient to account for the full activity of Twist. We identified a Twist target, the transmembrane protein T48, which acts in conjunction with G protein signaling to orchestrate shape changes. Together with G protein signaling, T48 recruits adherens junctions and the cytoskeletal regulator RhoGEF2 to the sites of apical constriction, ensuring rapid and intense changes in cell shape. |
| Databáze: | OpenAIRE |
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