Normalisation of prescribed dose in BNCT
| Autor: | J. R. Albritton, Peter J. Binns, Kent J. Riley, W. S. Kiger, Otto K. Harling |
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| Rok vydání: | 2007 |
| Předmět: |
medicine.medical_specialty
Internationality Boron Neutron Capture Therapy Common method Sensitivity and Specificity Imaging phantom Humans Dosimetry Medicine Radiology Nuclear Medicine and imaging Medical physics Radiometry Radiation treatment planning Neutrons Radiation Radiological and Ultrasound Technology business.industry Radiotherapy Planning Computer-Assisted Public Health Environmental and Occupational Health Reproducibility of Results Radiotherapy Dosage Equipment Design General Medicine Equipment Failure Analysis Absorbed dose business National laboratory Nuclear medicine |
| Zdroj: | Radiation Protection Dosimetry. 126:610-614 |
| ISSN: | 1742-3406 0144-8420 |
| DOI: | 10.1093/rpd/ncm124 |
| Popis: | Normalisation of prescribed dose in boron neutron capture therapy (BNCT) is needed to facilitate combining clinical data from different centres in the world to help expedite development of the modality. The approach being pursued within the BNCT community is based upon improving precision in the measurement and specification of absorbed dose. Beam characterisations using a common method are complete as are comparative dosimetry measurements between clinical centres in Europe and the USA. Results from treatment planning systems at these centres have been compared with measurements performed by MIT, and the scale factors determined are being confirmed with independent tests using measurements in an ellipsoidal water phantom. Dose normalisations have successfully been completed and applied to retrospectively analyse treatment plans from Brookhaven National Laboratory (1994-99) so that reported doses are consistently expressed with the trials performed during 1994-2003 at Harvard-MIT. Dose response relationships for adverse events and other endpoints can now be more accurately established. |
| Databáze: | OpenAIRE |
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