Breast cancer-related preferences among women with and without BRCA mutations
| Autor: | Ellen Warner, Alfred I. Neugut, Kimberly A. Hill, Judith S. Jacobson, Dawn L. Hershman, Eiran Warner, Anubha Bharthuar, Priya Patel, Wei-Yann Tsai, Victor R. Grann, Kristin E. Anderson |
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| Rok vydání: | 2009 |
| Předmět: |
Adult
Cancer Research medicine.medical_specialty Adolescent Cost effectiveness Genes BRCA2 Genes BRCA1 Breast Neoplasms Medical Oncology Breast cancer Quality of life medicine Mammography Humans Aged Gynecology Ovarian Neoplasms medicine.diagnostic_test Obstetrics business.industry Cancer Middle Aged medicine.disease Prophylactic Surgery Magnetic Resonance Imaging Quality-adjusted life year Oncology Mutation Quality of Life Female Breast disease business |
| Zdroj: | Breast cancer research and treatment. 119(1) |
| ISSN: | 1573-7217 |
| Popis: | Preference ratings are used to quantify quality of life in analyses used for health care policymaking. Subjects indicated how many years of their life expectancy they would trade to avoid BRCA mutations, breast/ovarian cancer, and five preventive measures including prophylactic surgery, annual mammograms, and annual magnetic resonance imaging (MRI). Among 243 respondents, both the 83 women with mutations and the 160 controls rated mammography highest (most favorably), MRI next highest, having a child with a mutation lowest, and ovarian cancer next lowest. Controls rated prophylactic surgery higher than cancer (P < 0.01), but women with mutations did not. In logistic regression, controls were twice as willing as women with mutations to trade time except for screening modalities; younger, lower-income, and non-white women were more willing to trade time than older, higher-income, and white women. Our findings support the use of average-risk individuals’ time trade-off preference ratings for health care policy development. |
| Databáze: | OpenAIRE |
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