Long-Term Results of Lipiodol-Transcatheter Arterial Embolization With Cisplatin or Doxorubicin for Unresectable Hepatocellular Carcinoma
| Autor: | Ryuichiro Ashikaga, Takayuki Yoshimasu, Koichi Fuji, Hiroshi Shindou, Yutaka Araki, Yasumasa Nishimura, Yukihiko Ono, Masaaki Inoue |
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| Rok vydání: | 2000 |
| Předmět: |
Adult
Male inorganic chemicals Cancer Research medicine.medical_specialty Carcinoma Hepatocellular medicine.medical_treatment Urology Antineoplastic Agents medicine Humans Doxorubicin Embolization Chemoembolization Therapeutic neoplasms Aged Retrospective Studies Cisplatin Chemotherapy business.industry Arterial Embolization Liver Neoplasms Iodized Oil Middle Aged medicine.disease Survival Analysis female genital diseases and pregnancy complications Catheter Oncology Hepatocellular carcinoma Lipiodol Female Nuclear medicine business medicine.drug |
| Zdroj: | American Journal of Clinical Oncology: Cancer Clinical Trials. 23:564-568 |
| ISSN: | 0277-3732 |
| Popis: | The long-term effects of Lipiodol-transcatheter arterial embolization (Lp-TAE) combined with cisplatin (CDDP) or doxorubicin (ADM) on unresectable hepatocellular carcinoma (HCC) were analyzed. Eighty-four consecutive patients with unresectable HCC were treated with TAE. Of the 84, 38 patients were treated with CDDP-Lp-TAE (CDDP group), whereas the remaining 46 patients were treated with ADM-Lp-TAE (ADM group). No significant difference in characteristics of patients and tumors was noted between the groups. CDDP (50 mg) or ADM (20-50 mg) was administered with Lp followed by embolization of the feeding arteries using gelatin sponge particles. The mean number of TAE treatments was 3.3 in the CDDP group and 1.9 in the ADM group (p < 0.01). The 5-year overall survival rates of the CDDP group and the ADM group were 19% and 6%, respectively. The overall survival rate of the CDDP group was significantly higher than that of the ADM group (p < 0.05). No serious side effects were observed in either group. CDDP-Lp-TAE improved the prognosis of unresectable HCC compared with ADM-Lp-TAE, which may be attributable to the fact that CDDP-Lp-TAE treatment could be repeated more times than ADM-Lp-TAE. |
| Databáze: | OpenAIRE |
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