Early tagging of cortical networks is required for the formation of enduring associative memory
| Autor: | Anne Hambucken, Pierre Trifilieff, Oliviero L. Gobbo, Stéphanie Alaux-Cantin, Edith Lesburguères, Bruno Bontempi |
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| Přispěvatelé: | Institut des Maladies Neurodégénératives [Bordeaux] (IMN), Université de Bordeaux (UB)-Centre National de la Recherche Scientifique (CNRS), CNRSFondation Simone et Cino del Duca Fédération pour la Recherche sur le CerveauAgence Nationale de la Recherche (ANR grant 09-MNPS-005-01) |
| Jazyk: | angličtina |
| Rok vydání: | 2011 |
| Předmět: |
Male
Memory Long-Term Computer science Hippocampus Brain imaging Receptors N-Methyl-D-Aspartate Synaptic Transmission Epigenesis Genetic Histones Rats Sprague-Dawley Food Preferences 03 medical and health sciences 0302 clinical medicine Encoding (memory) Neural Pathways Neuroplasticity Animals Learning Receptors AMPA Associative property 030304 developmental biology Memory consolidation Neurons 0303 health sciences Neuronal Plasticity Multidisciplinary Long-term memory Acetylation Cognition Content-addressable memory Frontal Lobe Rats Social transmission of food preference Odorants Synapses Cortex Rat [SDV.NEU]Life Sciences [q-bio]/Neurons and Cognition [q-bio.NC] Remote memory Excitatory Amino Acid Antagonists Reinforcement Psychology Neuroscience 030217 neurology & neurosurgery Signal Transduction |
| Zdroj: | Science Science, American Association for the Advancement of Science, 2011, 331 (6019), pp.924-928. ⟨10.1126/science.1196164⟩ |
| ISSN: | 0036-8075 1095-9203 |
| DOI: | 10.1126/science.1196164⟩ |
| Popis: | International audience; Although formation and stabilization of long-lasting associative memories are thought to require time-dependent coordinated hippocampal-cortical interactions, the underlying mechanisms remain unclear. Here, we present evidence that neurons in the rat cortex must undergo a "tagging process" upon encoding to ensure the progressive hippocampal-driven rewiring of cortical networks that support remote memory storage. This process was AMPA- and N-methyl-D-aspartate receptor-dependent, information-specific, and capable of modulating remote memory persistence by affecting the temporal dynamics of hippocampal-cortical interactions. Post-learning reinforcement of the tagging process via time-limited epigenetic modifications resulted in improved remote memory retrieval. Thus, early tagging of cortical networks is a crucial neurobiological process for remote memory formation whose functional properties fit the requirements imposed by the extended time scale of systems-level memory consolidation. |
| Databáze: | OpenAIRE |
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