Trends in candidemia and antifungal susceptibility in a university hospital in Northern Ireland 2001–2006
| Autor: | H.J. O'Neill, R. J. Hay, Ronan McMullan, Peter V. Coyle, M.J. Walker, C. H. Webb, Brian McCloskey, S. Hedderwick, L. Metwally |
|---|---|
| Rok vydání: | 2007 |
| Předmět: |
Microbiology (medical)
Antifungal Antifungal Agents Medical Records Systems Computerized medicine.drug_class Candida glabrata Microbial Sensitivity Tests Northern Ireland Methods laboratory Northern ireland Microbiology Hospitals University Prevalence Humans Medicine Mycosis Fungemia Candida Retrospective Studies business.industry Candidiasis bacterial infections and mycoses medicine.disease University hospital Corpus albicans Infectious Diseases business Fluconazole medicine.drug |
| Zdroj: | Journal of Infection. 55:174-178 |
| ISSN: | 0163-4453 |
| DOI: | 10.1016/j.jinf.2007.04.003 |
| Popis: | To describe the species distribution and antifungal susceptibility trends for documented episodes of candidemia at the Royal Hospitals, Belfast, 2001-2006.Laboratory-based retrospective observational study of all episodes of candidemia.There were 151 episodes of candidemia. The species recovered were: 96 C. albicans; 26 C. glabrata; 18 C. parapsilosis; five C. tropicalis; four C. guilliermondii; one C. famata and one C. dubliniensis. We separated the data into two periods 2001-2003 and 2004-2006; contrary to the findings of other investigators, there was a notable trends toward increasing frequency of C. albicans and decreasing frequency of non-albicans species over time. Although the proportion of C. albicans, C. parapsilosis and C. tropicalis isolates susceptible to fluconazole was unchanged over time, a trend of decreased susceptibility of C. glabrata to fluconazole was noted over the six-year period. Overall, 73% and 7.7% of C. glabrata isolates had susceptible-dose-dependent and resistant phenotypes, respectively. The percentage of C. glabrata isolates susceptible to fluconazole (MIC8 microg/ml) decreased from 36% in 2001-2003 to 0% in 2004-2006. Flucytosine resistance was detected in only 4 (2.7%) isolates. None of the isolates had an amphotericin B MIC1 microg/ml.A shift towards increasing dominance of C. albicans contrasts both with reports from other countries and previous data from Northern Ireland. Upwards fluconazole MIC drift among C. glabrata has important implications for empirical therapeutic decisions. |
| Databáze: | OpenAIRE |
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