An in vitro repositioning study reveals antifungal potential of chloroquine to inhibit growth and morphogenesis in Candida albicans
| Autor: | Ravikumar B. Shinde, Sandeep B. Rajput, S. Mohan Karuppayil, Jayant S. Raut |
|---|---|
| Rok vydání: | 2013 |
| Předmět: |
Drug
chemistry.chemical_classification Cisplatin Antifungal Agents biology media_common.quotation_subject Chloroquine Pharmacology biology.organism_classification Antimicrobial Applied Microbiology and Biotechnology Microbiology Multiple drug resistance Drug repositioning chemistry Ergosterol Candida albicans medicine Azole media_common medicine.drug |
| Zdroj: | The Journal of General and Applied Microbiology. 59:167-170 |
| ISSN: | 1349-8037 0022-1260 |
| DOI: | 10.2323/jgam.59.167 |
| Popis: | infections because of multiple drug resistance and alternate survival strate-gies like biofilm formation. Side effects due to toxicity is another problem associated with these drugs. Hence, there is a need to search for novel molecules with antifungal activities (Mishra et al. 2007; Oncu, 2011). Designing a new drug is a time- and money-consuming process. Drug repurposing/repositioning, which in-volves revealing novel bioactivities of drugs already being used in therapeutics (for treatment of a different ailment), is an attractive strategy (Ashburn and Thor, 2004). For example, cisplatin, which was originally dis -covered as an antimicrobial, proved to be an effective tumor inhibitor. Azole antifungals were shown to have good anti-mycobacterium activities, while anticancer agents were reported to possess potential anti |
| Databáze: | OpenAIRE |
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