The Diagnostic Value of Protein Clearances in Rejection of Human Renal Allografts
| Autor: | Jensen Ha, Dr.P. Skaarup, L. Hemmingsen, P. Jest |
|---|---|
| Rok vydání: | 2009 |
| Předmět: |
Adult
Graft Rejection Male medicine.medical_specialty Adolescent Kidney Gastroenterology Urinary excretion Internal medicine Internal Medicine medicine False positive paradox Humans Transplantation Homologous Positive test Child chemistry.chemical_classification Haptoglobins biology business.industry Haptoglobin Transferrin Blood Proteins Middle Aged Prognosis Kidney Transplantation Immunoglobulin A Transplantation Urinary obstruction chemistry Renal transplant Child Preschool Creatinine Immunoglobulin G Immunology biology.protein Female business |
| Zdroj: | Acta Medica Scandinavica. 203:107-112 |
| ISSN: | 0001-6101 |
| DOI: | 10.1111/j.0954-6820.1978.tb14839.x |
| Popis: | The relative clearances of transferrin, haptoglobin, IgG, and IgA were used as a diagnostic test for detection of acute rejection episodes after renal transplantation, using an automated immunoprecipitin reaction. Thirty-six out of 40 rejections were predicted by 0--5 days. The sensitivity and specificity were 90% and 98%, respectively. The predictive value of a positive diagnostic test was 86% and of a negative 99%. False positives caused by fever and urinary obstruction could probably be excluded by the finding of an increased urinary excretion of beta2-microglobulin prior to the increased relative clearance of transferrin, haptoglobin, IgG and IgA. This would improve the predictive value of a positive test to 95%. Daily or more frequent protein clearance determinations should be performed in renal transplant patients, since the method used was easy, rapid and suited for sequential analysis, and the procedure was without risk for the patient. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
|