Non-surgically related causes of erectile dysfunction after bilateral nerve-sparing radical prostatectomy
| Autor: | Giorgio Gandaglia, Giuliana Lista, Lorenzo Bianchi, Alberto Briganti, S.F. Shariat, Nazareno Suardi, Marco Moschini, Andrea Salonia, M. S. Rossi, Riccardo Schiavina, Nicola Fossati, F. Montorsi, Andrea Gallina |
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| Přispěvatelé: | Gandaglia G1, 2, Lista, G, Fossati, N, Suardi, N, Gallina, A, Moschini, M, Bianchi, L, Rossi, M, Schiavina, R, Shariat, Sf, Salonia, A, Montorsi, F, Briganti, A, Gandaglia, G., Lista, G., Fossati, N., Suardi, N., Gallina, A., Moschini, M., Bianchi, L., Rossi, M. S., Schiavina, R., Shariat, S. F., Salonia, Andrea, Montorsi, Francesco, Briganti, A. |
| Rok vydání: | 2016 |
| Předmět: |
Male
Cancer Research medicine.medical_specialty Biopsy Urology medicine.medical_treatment 030232 urology & nephrology Prostatitis Kaplan-Meier Estimate 03 medical and health sciences 0302 clinical medicine Erectile Dysfunction Retrospective Studie Humans Medicine Depression (differential diagnoses) Aged Neoplasm Staging Proportional Hazards Models Retrospective Studies Prostatectomy business.industry Proportional hazards model Prostatic Neoplasms Retrospective cohort study Middle Aged medicine.disease Prostate-specific antigen Erectile dysfunction Oncology 030220 oncology & carcinogenesis Prostatic Neoplasm Proportional Hazards Model Benign prostatic hyperplasia (BPH) Neoplasm Grading Non-surgically related causes of erectile dysfunction after bilateral nerve-sparing radical prostatectomy business Human |
| Zdroj: | Prostate Cancer and Prostatic Diseases. 19:185-190 |
| ISSN: | 1476-5608 1365-7852 |
| DOI: | 10.1038/pcan.2016.1 |
| Popis: | Background:Erectile dysfunction (ED) represents one of the most common long-term side effects in prostate cancer (PCa) patients treated with bilateral nerve-sparing radical prostatectomy (BNSRP). The aim of our study was to assess the influence of non-surgically related causes of ED in patients treated with BNSRP.Methods:Overall, 716 patients treated with BNSRP were retrospectively identified. All patients had complete data on erectile function (EF) assessed by the Index of Erectile Function-EF domain (IIEF-EF) and depressive status assessed by the Center for Epidemiologic Studies-Depression (CES-D) questionnaire. EF recovery was defined as an IIEF-EF of â¥22. Kaplan-Meier analyses assessed the impact of preoperative IIEF-EF, depression and adjuvant radiotherapy (aRT) on the time to EF recovery. Multivariable Cox regression models were used to test the impact of aRT on EF recovery after accounting for depression and baseline IIEF-EF.Results:Median follow-up was 48 months. Patients with a preoperative IIEF-EF of â¥22 had substantially higher EF recovery rates compared with those with a lower IIEF-EF (P |
| Databáze: | OpenAIRE |
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