Risks Associated With the Transfusion of Various Blood Products in Aortic Valve Replacement
Autor: | Alain Dardashti, Per Ederoth, Faleh Al-Rashidi, Lars Algotsson, Henrik Bjursten, Björn Brondén |
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Jazyk: | angličtina |
Rok vydání: | 2013 |
Předmět: |
Pulmonary and Respiratory Medicine
medicine.medical_specialty Time Factors Platelet Transfusion law.invention Plasma Aortic valve replacement law Risk Factors Internal medicine Cardiopulmonary bypass medicine Humans Platelet Blood Transfusion Cardiac and Cardiovascular Systems Coronary Artery Bypass Retrospective Studies Heart Valve Prosthesis Implantation Ejection fraction biology business.industry C-reactive protein Hazard ratio Transfusion Reaction Middle Aged medicine.disease Red blood cell medicine.anatomical_structure Aortic Valve Cardiology biology.protein Surgery Cardiology and Cardiovascular Medicine business Erythrocyte Transfusion Transfusion-related acute lung injury |
Zdroj: | Annals of Thoracic Surgery; 96(2), pp 494-499 (2013) |
ISSN: | 1552-6259 |
Popis: | Patients undergoing cardiac operations often require transfusions of red blood cells, plasma, and platelets. From a statistical point of view, there is a significant collinearity between the components, but they differ in indications for use and composition. This study explores the relationship between the transfusion of different blood components and long-term mortality in patients undergoing aortic valve replacement alone or combined with revascularization.A retrospective single-center study was performed including 1,311 patients undergoing aortic valve replacement. Patients who received more than 7 units of red blood cells, those who died early (7 days), and emergency cases were excluded. Patients were monitored for up to 9.5 years. A broad selection of potential risk factors were analyzed using Cox proportional hazards regression, where transfusion of red blood cells, plasma, and platelets were forced to remain in the model.The transfusion of red blood cells was not associated with decreased long-term survival (hazard ratio [HR], 1.01; p = 0.520) nor was the transfusion of platelets (HR, 0.946; p = 0.124); however, the transfusion of plasma was (HR, 1.041; p0.001). All HRs are per unit of blood product transfused. No increased risk was found for patients undergoing a combined procedure.No significant risk for long-term mortality was associated with transfusion of red blood cells during the study period. However, the transfusion of plasma was associated with increased mortality. |
Databáze: | OpenAIRE |
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