Circulating angiogenic profiles and histo-morphological placental characteristics of uncomplicated post-date pregnancies
| Autor: | Meryam Sugulle, Sophie Bowe, Gitta Turowski, Anne Cathrine Staff, Birgitte Mitlid-Mork |
|---|---|
| Rok vydání: | 2021 |
| Předmět: |
Adult
Male 0301 basic medicine Placental growth factor Placenta Pregnancy Trimester Third Gestational Age Fibrin Infant Postmature Andrology 03 medical and health sciences 0302 clinical medicine Pregnancy medicine Humans 030219 obstetrics & reproductive medicine biology business.industry Confounding Infant Newborn Obstetrics and Gynecology medicine.disease 030104 developmental biology Reproductive Medicine Case-Control Studies embryonic structures biology.protein Mann–Whitney U test Gestation Angiogenesis Inducing Agents Female business Biomarkers Soluble fms-like tyrosine kinase-1 Developmental Biology |
| Zdroj: | Placenta. 109:55-63 |
| ISSN: | 0143-4004 |
| DOI: | 10.1016/j.placenta.2021.04.017 |
| Popis: | Introduction The objectives of this study were to describe the histo-morphology of post-date placentas in clinically uncomplicated pregnancies without adverse delivery outcomes and the association with maternal circulating pre-delivery Placental Growth Factor (PlGF) and soluble fms-like tyrosine kinase-1 (sFlt-1), as well as the sFlt-1/PlGF ratio. Methods Post-date placentas (gestational week ≥40+2, n = 87) were macroscopically and histo-morphologically assessed according to the international, standardized Amsterdam Workshop Consensus Group criteria. Inter-rater agreement was evaluated by percentage of agreement. PlGF and sFlt-1 concentrations were available from maternal serum sampled close to delivery, and were compared by Mann-Whitney U test. Linear regression analyses were adjusted for predefined potential confounders. Results The majority of the post-date placentas showed morphological signs of delayed maturation. About half of the placentas showed increased syncytial knotting and fibrin. In placentas with increased presence of intervillous fibrin, median maternal PlGF level was significantly lower (p = 0.004), median sFlt-1 level higher and sFlt-1/PlGF ratio significantly higher (p = 0.002) compared to those with normal fibrin amounts. Increased placental syncytial knotting was associated with lower levels of PlGF, higher sFlt-1 and higher sFlt-1/PlGF ratio compared to those with normal knotting. Discussion Our standardized morphological study of post-date placentas in clinically healthy women with uncomplicated pregnancies and delivery outcomes revealed delayed maturation in the majority of placentas. Increased pre-delivery circulating anti-angiogenic profile was associated with increased intervillous fibrin and syncytial knotting. We propose that circulating maternal angiogenic biomarkers may be of future use in clinical post-date pregnancy assessment, as they reflect important aspects of placental health and function. |
| Databáze: | OpenAIRE |
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