Focus on Cardiologic Findings in 30 Children With PANS/PANDAS: An Italian Single-Center Observational Study
| Autor: | Cristiana Alessia Guido, Giulia Capata, Davide Maria Biancone, Manuel Murciano, Vanessa Martucci, Isabella Tristano, Lorenzo Loffredo, Marzia Duse, Silvia Anaclerio, Anna Maria Zicari, Alberto Spalice |
|---|---|
| Rok vydání: | 2019 |
| Předmět: |
Pediatrics
medicine.medical_specialty Tics PANDAS (Pediatric Autoimmune Neuropsychiatric Disorders Associated with Streptococcal Infection) Physical examination heart murmurs 030204 cardiovascular system & hematology mitral valve (mv) 03 medical and health sciences 0302 clinical medicine PANDAS 030225 pediatrics cardiologic consultation pandas (pediatric autoimmune neuropsychiatric disorders associated with streptococcal infection) pans (pediatric acute-onset neuropsychiatric syndrome) pediatry streptococcus beta hemolytic tics Streptococcus beta hemolytic Medicine medicine.diagnostic_test business.industry lcsh:RJ1-570 lcsh:Pediatrics Chorea Brief Research Report medicine.disease Pediatrics Perinatology and Child Health Etiology Rheumatic fever Observational study PANS (Pediatric Acute-onset Neuropsychiatric Syndrome) medicine.symptom business Medical literature |
| Zdroj: | Frontiers in Pediatrics, Vol 7 (2019) Frontiers in Pediatrics |
| ISSN: | 2296-2360 |
| DOI: | 10.3389/fped.2019.00395 |
| Popis: | Objective: Cardiac involvement in PANS has not been clarified relying on the scientific literature available until today. It is known that streptococcal infections play a role in the etiology of a great number of diseases including Sydenham chorea and rheumatic fever, among others. Based on the suspected pathogenesis of PANDAS (Pediatric Autoimmune Neuropsychiatric Disorders Associated with Streptococcal infections) reported in the medical literature, we decided to investigate the cardiologic involvement in children with a recent PANS/PANDAS diagnosis. Methods: The study population satisfies PANS (1) and PANDAS (2) criteria of diagnoses. Cardiologic assessment was performed through clinical examination, electrocardiography, and echocardiography. Results: In the selected pediatric population, a significant number of children presented mitral valve involvement, systolic murmurs and electrocardiographic abnormalities. High ASLOT levels did not seem to be associated to a cardiac involvement. Conclusions: Often PANS is difficult to diagnose because it is little known by physicians and most of the cardiologic findings described in this study are common among the healthy pediatric population. Also, ASLOT levels seems not to be predictive of cardiac involvement. Furthermore, the existence of PANDAS as a clinical entity is associated with a group of anti-neuronal autoantibodies found in Sydenham chorea is still controversial. We recommend a complete cardiologic evaluation in those children who meet the PANS/PANDAS diagnostic criteria. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
|