Dissecting molecular cross-talk between Nrf2 and NF-κB response pathways
| Autor: | Amy H. Ponsford, Christopher M. Sanderson, Joanna D. Wardyn |
|---|---|
| Jazyk: | angličtina |
| Rok vydání: | 2015 |
| Předmět: |
NF-E2-Related Factor 2
S7 Inflammation Biology medicine.disease_cause Biochemistry The Keap1/Nrf2 Pathway in Health and Disease 03 medical and health sciences chemistry.chemical_compound 0302 clinical medicine medicine Kelch-like ECH-associated protein 1 (Keap1) Animals Humans Transcription factor 030304 developmental biology Regulation of gene expression 0303 health sciences Neurodegeneration inhibitor of kappa light polypeptide gene enhancer in B-cells kinase beta (IKKβ) neurodegeneration NF-kappa B NF-κB haeme oxygenase-1 (HO-1) NFKB1 medicine.disease nuclear factor (erythroid-derived 2)-like 2 (Nrf2) 3. Good health Cell biology Oxidative Stress chemistry Gene Expression Regulation Immunology nuclear factor-κB (NF-κB) Cytokines medicine.symptom Signal transduction Nervous System Diseases Biochemical Society Focused Meetings 030217 neurology & neurosurgery Oxidative stress Signal Transduction |
| Zdroj: | Biochemical Society Transactions |
| ISSN: | 1470-8752 0300-5127 |
| Popis: | In most tissues, cells are exposed to frequent changes in levels of oxidative stress and inflammation. Nuclear factor (erythroid-derived 2)-like 2 (Nrf2) and nuclear factor-κB (NF-κB) are the two key transcription factors that regulate cellular responses to oxidative stress and inflammation respectively. Pharmacological and genetic studies suggest that there is functional cross-talk between these two important pathways. The absence of Nrf2 can exacerbate NF-κB activity leading to increased cytokine production, whereas NF-κB can modulate Nrf2 transcription and activity, having both positive and negative effects on the target gene expression. This review focuses on the potentially complex molecular mechanisms that link the Nrf2 and NF-κB pathways and the importance of designing more effective therapeutic strategies to prevent or treat a broad range of neurological disorders. |
| Databáze: | OpenAIRE |
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