Radioembolization Dosimetry with Total-Body (90)Y PET
| Autor: | Heather Hunt, Denise Caudle, Benjamin Spencer, Emilie Roncali, Negar Omidvari, Michael Rusnak, Gustavo Coelho Alves Costa, Cameron C. Foster, Rex Pillai, Catherine T. Vu |
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| Jazyk: | angličtina |
| Rok vydání: | 2022 |
| Předmět: |
radioembolization
Materials science Tare weight Clinical Sciences Bioengineering Phantoms Imaging phantom Imaging Basic Science Investigation Rare Diseases Clinical Research Positron Emission Tomography Computed Tomography medicine Image noise Dosimetry Humans Radiology Nuclear Medicine and imaging Yttrium Radioisotopes Radiometry 90Y Monte Carlo simulation Cancer PET-CT medicine.diagnostic_test business.industry Phantoms Imaging Liver Disease radionuclide therapy personalized medicine Y-90 microspheres Nuclear Medicine & Medical Imaging Good Health and Well Being Positron emission tomography Absorbed dose Radionuclide therapy Biomedical Imaging Digestive Diseases Nuclear medicine business Monte Carlo Method |
| Zdroj: | J Nucl Med Journal of nuclear medicine : official publication, Society of Nuclear Medicine, vol 63, iss 7 |
| Popis: | Transarterial radioembolization (TARE) is a locoregional radiopharmaceutical therapy based on the delivery of radioactive (90)Y microspheres to liver tumors. The importance of personalized dosimetry to make TARE safer and more effective has been demonstrated in recent clinical studies, stressing the need for quantification of the dose–response relationship to ultimately optimize the administered activity before treatment and image it after treatment. (90)Y dosimetric studies are challenging because of the lack of accurate and precise methods but are best realized with PET combined with Monte Carlo simulations and other image modalities to calculate a segmental dose distribution. The aim of this study was to assess the suitability of imaging (90)Y PET patients with the total-body PET/CT uEXPLORER and to investigate possible improvements in TARE (90)Y PET-based dosimetry. The uEXPLORER is the first commercially available ultra-high-resolution (171 cps/kBq) total-body digital PET/CT device with a 194-cm axial PET field of view that enables the whole body to be scanned at a single bed position. Methods: Two PET/CT scanners were evaluated in this study: the Biograph mCT and the total-body uEXPLORER. Images of a National Electrical Manufacturers Association (NEMA) image-quality phantom and 2 patients were reconstructed using our standard clinical oncology protocol. A late portal phase contrast-enhanced CT scan was used to contour the liver segments and create corresponding volumes of interest. To calculate the absorbed dose, Monte Carlo simulations were performed using Geant4 Application for Tomographic Emission (GATE). The absorbed dose and dose–volume histograms were calculated for all 6 spheres (diameters ranging from 10 to 37 mm) of the NEMA phantom, the liver segments, and the entire liver. Differences between the phantom doses and an analytic ground truth were quantified through the root mean squared error. Results: The uEXPLORER showed a higher signal-to-noise ratio at 10- and 13-mm diameters, consistent with its high spatial resolution and system sensitivity. The total liver-absorbed dose showed excellent agreement between the uEXPLORER and the mCT for both patients, with differences lower than 0.2%. Larger differences of up to 60% were observed when comparing the liver segment doses. All dose–volume histograms were in good agreement, with narrower tails for the uEXPLORER in all segments, indicating lower image noise. Conclusion: This patient study is compelling for the use of total-body (90)Y PET for liver dosimetry. The uEXPLORER scanner showed a better signal-to-noise ratio than mCT, especially in lower-count regions of interest, which is expected to improve dose quantification and tumor dosimetry. |
| Databáze: | OpenAIRE |
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