Positive Response to Trastuzumab in a Case of HER2-Overexpressing Metastatic Gastric Cancer that Presented as Severe Thrombocytopenia
| Autor: | Sung-Nam Lim, Ho-Chang Lee, Ok-Jun Lee, Jeong Tae Kim, Seung Taik Kim, Jae Hyun Choi, Hye-Suk Han, Ki Hyeong Lee |
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| Rok vydání: | 2011 |
| Předmět: |
Male
Cancer Research Receptor ErbB-2 medicine.drug_class Antineoplastic Agents Antibodies Monoclonal Humanized Monoclonal antibody Metastatic gastric cancer Stomach Neoplasms Trastuzumab Humans Medicine skin and connective tissue diseases neoplasms Human Epidermal Growth Factor Receptor 2 integumentary system business.industry Carcinoma fungi food and beverages Hematology General Medicine Middle Aged Thrombocytopenia Severe thrombocytopenia Up-Regulation Treatment Outcome Positive response Oncology Immunology Cancer research business medicine.drug |
| Zdroj: | Onkologie. 34:621-624 |
| ISSN: | 1423-0240 0378-584X |
| DOI: | 10.1159/000334055 |
| Popis: | Trastuzumab, a humanized monoclonal antibody directed against human epidermal growth factor receptor 2 (HER2), has been shown to be active against metastatic gastric cancers that overexpress HER2.A 47-year-old man presented with a headache and visual disturbance. He was subsequently found to have an intracranial hemorrhage. Laboratory testing showed severe thrombocytopenia, and a bone marrow biopsy revealed aggregates of malignant tumor cells. Endoscopic biopsy of an ulcerative lesion of the gastric antrum confirmed signet ring cell carcinoma based on the results of HE staining. Immunohistochemistry of the tumor cells revealed HER2 overexpression with an intensity of 3+, and silver in situ hybridization showed HER2 gene amplification. The patient was treated with trastuzumab because of the presence of severe thrombocytopenia. After 2 months of trastuzumab therapy, gastric wall thickening and ascites were diminished and thrombocytopenia was markedly improved. Trastuzumab was continued for an additional 3 months.This is the first report of a positive response to trastuzumab in a patient with HER2-overexpressing metastatic gastric cancer that was accompanied by bone marrow involvement and severe thrombocytopenia. This finding is of considerable relevance for difficult cases of metastatic gastric cancer that preclude the administration of aggressive antineoplastic regimens. |
| Databáze: | OpenAIRE |
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