Thyroid stimulating hormone elevation without antithyroid antibody elevation in nursing home patients
| Autor: | Elizabeth Langer, Wolfram E. Nolten, Paul J. Drinka, Susan K. Voeks |
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| Rok vydání: | 1991 |
| Předmět: |
Male
endocrine system medicine.medical_specialty endocrine system diseases Thyroid Gland Thyrotropin Antibodies Lesion Wisconsin Thyroid-stimulating hormone Reference Values Internal medicine medicine Homes for the Aged Humans Aged Veterans Aged 80 and over biology business.industry Thyroid disease Thyroid Antibody titer Middle Aged medicine.disease Anti-thyroid autoantibodies Nursing Homes Elevation (emotion) medicine.anatomical_structure Endocrinology biology.protein Female Geriatrics and Gerontology medicine.symptom Antibody business hormones hormone substitutes and hormone antagonists |
| Zdroj: | Journal of the American Geriatrics Society. 39(10) |
| ISSN: | 0002-8614 |
| Popis: | Objectives: To investigate the relationship between antithyroid antibody elevation and thyrotropin (TSH) elevation. Setting: Large state veterans home. Methods: Seven hundred seventy-six residents were screened for TSH elevation. Seventy-two residents with TSH elevation and no history of thyroid disease or recent iodine exposure later had determinations of antithyroglobulin and antimicrosomal antibodies. The relationship between TSH levels and antibody titers was explored. Results: Eleven percent of the residents had TSH elevation. Thirty-two percent of men and 64% of women with TSH elevation had elevation of antithyroid antibodies. Those residents with the highest antithyroid antibody titers had significantly greater TSH elevation. Conclusion: Previous investigators have found similar percentages of individuals with TSH elevation who lack antithyroid antibody elevation. We hypothesize that TSH elevation without elevated antibody titers may be the result of a previously described involutional histologic lesion of the thyroid. |
| Databáze: | OpenAIRE |
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