Reckless generosity, parkinson's disease and dopamine: A case series and literature review
| Autor: | Julia Muellner, Marie Elise Maradan-Gachet, Joan P. Michelis, Martin Lenard Lachenmayer, Deborah Amstutz, Paul Krack, Kyrill Schwegler, Ines Debove |
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| Rok vydání: | 2021 |
| Předmět: |
0301 basic medicine
Generosity medicine.medical_specialty Behavioral addiction Parkinson's disease impulse control disorders altruistic behavior media_common.quotation_subject 610 Medicine & health Disease 030105 genetics & heredity generosity 03 medical and health sciences 0302 clinical medicine Dopamine medicine Psychiatry Case Series with Literature Review media_common Discounting Dopaminergic medicine.disease Neurology Healthy individuals Neurology (clinical) dopamine medicine.symptom Psychology 030217 neurology & neurosurgery behavioral addiction medicine.drug |
| Zdroj: | Movement Disorders Clinical Practice Amstutz, Deborah; Michelis, Joan Philipp; Debove, Ines; Maradan-Gachet, Marie-Elise; Lachenmayer, Martin Lenard; Muellner, Julia; Schwegler, Kyrill; Krack, Paul (2021). Reckless generosity, parkinson's disease and dopamine: A case series and literature review. Movement disorders clinical practice, 8(3), pp. 469-473. Wiley 10.1002/mdc3.13156 |
| DOI: | 10.48350/152177 |
| Popis: | Background Impulse control disorders (ICDs) are a frequent side effect of dopamine replacement therapy (DRT) in Parkinson's disease (PD). Reckless generosity might expand the spectrum of known ICDs. Cases Over 18 months, we encountered three PD patients exhibiting reckless generosity under DRT, leading to disastrous financial and social consequences. Literature Review Except for another case series describing reckless generosity in three PD patients, only one study has examined generosity in PD patients; with findings suggesting that PD patients with ICDs are less sensitive to the aversive aspects of the lack of reciprocation in social settings. Studies with healthy individuals suggest that increased availability of dopamine might reduce social discounting and promote egalitarian behavior, and thereby increase generous behavior towards strangers. Genetic studies show that polymorphisms in dopamine D4 receptors influence generous behavior. Conclusions Reckless generosity in PD patients with DRT might be underreported and should therefore be carefully be screened for by clinicians. A potential mechanism underlying this ICD‐related behavior might be a sensitization of the mesolimbic and mesocortical dopaminergic system, leading to reduced social discounting and maladaptive reward‐learning. Further research is needed to investigate the prevalence and underlying mechanisms of reckless generosity in PD patients. |
| Databáze: | OpenAIRE |
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