Effect of Cinacalcet on the Redox Status of Albumin in Secondary Hyperparathyroidism Patients Receiving Hemodialysis
| Autor: | Kazutaka Matsushita, Shigeyuki Miyamura, Hirotaka Komaba, Koki Tokunaga, Shoma Tanaka, Takehiro Nakano, Masaki Otagiri, Toru Maruyama, Motoko Tanaka, Tadashi Imafuku, Hitoshi Maeda, Kenshiro Hirata, Masafumi Fukagawa, Daisuke Kadowaki, Hiroshi Watanabe, Hiromasa Kato |
|---|---|
| Rok vydání: | 2020 |
| Předmět: |
Adult
Male 0301 basic medicine medicine.medical_specialty Cinacalcet Calcium-Regulating Hormones and Agents Calcimimetic medicine.medical_treatment Pharmaceutical Science Parathyroid hormone Serum Albumin Human medicine.disease_cause Antioxidants 03 medical and health sciences 0302 clinical medicine Renal Dialysis Internal medicine medicine Humans Aged Pharmacology business.industry Albumin General Medicine Middle Aged medicine.disease Treatment Outcome 030104 developmental biology Endocrinology Parathyroid Hormone 030220 oncology & carcinogenesis Female Hyperparathyroidism Secondary Secondary hyperparathyroidism Hemodialysis business Oxidation-Reduction Oxidative stress Kidney disease medicine.drug |
| Zdroj: | Biological and Pharmaceutical Bulletin. 43:1583-1590 |
| ISSN: | 1347-5215 0918-6158 |
| Popis: | Chronic kidney disease (CKD) patients with secondary hyperparathyroidism (SHPT) have an increased risk of cardiovascular disease (CVD). Cinacalcet is a calcimimetic that permits impaired endothelial functions to be recovered via inhibiting parathyroid hormone (PTH) production in SHPT patients. However, the underlying mechanism for its action remains unknown. The purpose of this study was to examine the effect of cinacalcet on the redox state of human serum albumin (HSA), a reliable marker for assessing endothelial oxidative damage in SHPT patients who were receiving hemodialysis. Cinacalcet was administered to six SHPT patients for a period of 8 weeks. After 4 weeks of treatment, cinacalcet significantly decreased the oxidized albumin ratio which is a ratio of reduced and oxidized forms of HSA via increasing reduced form of HSA. Moreover, the radical scavenging abilities of HSA that was isolated from SHPT patients were increased by cinacalcet, suggesting the recovery of the impaired vascular anti-oxidant ability. Interestingly, the oxidized albumin ratio in SHPT patients was significantly higher than that in hemodialysis patients. In addition, the changes of intact PTH levels were significantly correlated with the oxidized albumin ratio. It therefore appears that PTH may induce oxidative stress in SHPT patients. In fact, an active analogue of PTH increased the production of reactive oxygen species in human endothelial cells. Thus, cinacalcet exhibits anti-oxidative activity through its pharmacological action. Additionally, cinacalcet itself showed radical scavenging activity. In conclusion, cinacalcet improves the redox status of HSA by inhibiting PTH production and partially by its radical scavenging action. |
| Databáze: | OpenAIRE |
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