Continuous glucose monitoring reduces pubertal hyperglycemia of type 1 diabetes
| Autor: | Shamima Yeasmin, Bruce A. Barton, Laura C. Alonso, Gabrielle Jasmin, Shwetha Rupendu, Emily Zitek-Morrison, Sanaa Ayyoub, Sadichchha Parajuli, Benjamin U. Nwosu, Tony R Villalobos-Ortiz, Bita Zahedi |
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| Rok vydání: | 2020 |
| Předmět: |
Blood Glucose
Male Diabetes duration medicine.medical_specialty Adolescent endocrine system diseases Endocrinology Diabetes and Metabolism Urology Insulin delivery 030209 endocrinology & metabolism Article 03 medical and health sciences 0302 clinical medicine Endocrinology Diabetes management Humans Medicine Longitudinal Studies 030212 general & internal medicine Child Retrospective Studies Glycemic Glycated Hemoglobin Type 1 diabetes Continuous glucose monitoring business.industry Blood Glucose Self-Monitoring Poor glycemic control Puberty nutritional and metabolic diseases medicine.disease Diabetes Mellitus Type 1 Case-Control Studies Child Preschool Hyperglycemia Pediatrics Perinatology and Child Health Cohort Female business |
| Zdroj: | J Pediatr Endocrinol Metab |
| ISSN: | 2191-0251 0334-018X |
| DOI: | 10.1515/jpem-2020-0057 |
| Popis: | Background Physiologic hyperglycemia of puberty is a major contributor to poor glycemic control in youth with type 1 diabetes (T1D). This study’s aim was to determine the effectiveness of continuous glucose monitoring (CGM) to improve glycemic control in pubertal youth with T1D compared to a non-CGM cohort after controlling for age, sex, BMI, duration, and insulin delivery methodology. The hypothesis is that consistent CGM use in puberty improves compliance with diabetes management, leading to increased percentage (%) time in range (TIR70–180 mg/dL) of glycemia, and lowering of HbA1c. Methods A longitudinal, retrospective, case-controlled study of 105 subjects consisting of 51 T1D controls (60.8% male) age 11.5 ± 3.8 y; and 54 T1D subjects (48.1% male) age 11.1 ± 5.0 y with confirmed CGM use for 12 months. Pubertal status was determined by Tanner staging. Results were adjusted for baseline HbA1c and diabetes duration. Results HbA1c was similar between the controls and the CGM group at baseline: 8.2 ± 1.1% vs 8.3 ± 1.2%, p=0.48 respectively; but was significantly lower in the CGM group 12 months later, 8.2 ± 1.1% vs. 8.7 ± 1.4%, p=0.035. Longitudinal change in HbA1c was similar in the prepubertal cohort between the control- and CGM groups: −0.17 ± 0.98% vs. 0.38 ± 1.5%, p=0.17. In contrast, HbA1c increased with advancing age and pubertal status in the pubertal controls but not in the pubertal CGM group: 0.55 ± 1.4 vs −0.22 ± 1.1%, p=0.020. Percent TIR was inversely related to HbA1c in the CGM group, r=-0.6, p=0.0004, for both prepubertal and pubertal subjects. Conclusions CGM use significantly improved glycemic control in pubertal youth with T1D compared to non-CGM users. |
| Databáze: | OpenAIRE |
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