Expression and Prognostic Significance of Macrophage Inflammatory Protein-3 Alpha and Cystatin A in Nasopharyngeal Carcinoma
| Autor: | Weiming Zhong, Ai-Ying Lu, Yuming Zheng, Cheng Li, Jun Li, Minzhong Tang, Ningjiang Ou, Yong-Lin Cai, Jianquan Gao, Liping Ma |
|---|---|
| Jazyk: | angličtina |
| Rok vydání: | 2015 |
| Předmět: |
Adult
Male China medicine.medical_specialty Pathology Article Subject Nasopharyngeal neoplasm lcsh:Medicine Risk Assessment Sensitivity and Specificity Gastroenterology General Biochemistry Genetics and Molecular Biology Internal medicine Biomarkers Tumor Prevalence Carcinoma Humans Medicine Cystatin A Stage (cooking) Survival rate Aged Chemokine CCL20 Nasopharyngeal Carcinoma General Immunology and Microbiology business.industry lcsh:R Reproducibility of Results Nasopharyngeal Neoplasms General Medicine Middle Aged Prognosis medicine.disease Primary tumor Survival Rate stomatognathic diseases Treatment Outcome Nasopharyngeal carcinoma Immunohistochemistry Female business Research Article |
| Zdroj: | BioMed Research International, Vol 2015 (2015) BioMed Research International |
| ISSN: | 2314-6141 2314-6133 |
| Popis: | This study aims to investigate the expression of macrophage inflammatory protein-3 alpha (MIP-3α) and cystatin A in nasopharyngeal carcinoma (NPC) and their association with clinical characteristics and prognosis. Primary tumor specimens from 114 NPC patients and associated clinical follow-up data were collected, and the expression of MIP-3αand cystatin A proteins was investigated by immunohistochemistry. Expression of MIP-3αwas significantly associated with TNM stage in patients with NPC (P<0.05). NPC patients with positive expression of MIP-3αexhibited shorter median overall survival (OS) and distant metastasis-free survival (DMFS), compared with patients with negative expression (OS: 50.5 months versus 59.0 months,P=0.013; DMFS: 50.1 months versus 60.2 months,P=0.003). NPC patients with positive expression of cystatin A exhibited shorter median OS, local recurrence-free survival (LRFS), and DMFS, compared with patients with negative expression (OS: 51.1 months versus 60.0 months,P=0.004; LRFS: 54.5 months versus 59.5 months,P=0.036; DMFS: 52.3 months versus 58.8 months,P=0.036). Both MIP-3αand cystatin A overexpressions in NPC tumor tissues were strong independent factors of poor prognosis in NPC patients. MIP-3αand cystatin A expressions may be valuable prognostic markers in NPC patients. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
|