Vascular Endothelial Function as a Valid Predictor of Variations in Pulmonary Function in T2DM Patients Without Related Complications
| Autor: | He Tai, Xiao-lin Jiang, Si-cheng Yao, Ye Liu, Hong Wei, Ling-bing Li, Zeng-jin Jiao, Tian-qing Wang, Jin-song Kuang, Lian-qun Jia |
|---|---|
| Rok vydání: | 2020 |
| Předmět: |
Diabetes duration
Adult Blood Glucose Male medicine.medical_specialty type 2 diabetes mellitus Endocrinology Diabetes and Metabolism 030209 endocrinology & metabolism predictor 030204 cardiovascular system & hematology Nitric Oxide lcsh:Diseases of the endocrine glands. Clinical endocrinology Nitric oxide Pulmonary function testing Lesion 03 medical and health sciences chemistry.chemical_compound 0302 clinical medicine Endocrinology Internal medicine Diabetes mellitus medicine Humans In patient Lung Original Research vascular endothelial function lcsh:RC648-665 Endothelin-1 business.industry pulmonary function Healthy subjects Type 2 Diabetes Mellitus Middle Aged medicine.disease early stage chemistry Diabetes Mellitus Type 2 Cardiology Female Endothelium Vascular medicine.symptom business |
| Zdroj: | Frontiers in Endocrinology Frontiers in Endocrinology, Vol 12 (2021) |
| ISSN: | 1664-2392 |
| Popis: | To assess the variations in pulmonary function and vascular endothelial function in their early stages (without related complications). A total of 162 type 2 diabetes mellitus (T2DM) patients without diabetes complications and 55 healthy people were selected, comprising the T2DM group and the control group, respectively, to evaluate changes in vascular endothelial function and lung function and determine the correlation between them. In this study, the T2DM group exhibited significantly lower pulmonary function than that of the control group (P < 0.05). The T2DM group also showed significantly lower flow-mediated dilation (FMD) and nitric oxide (NO) (P < 0.05) than those of the control group. Pulmonary functional indexes correlated positively with FMD and NO (P < 0.05) and correlated negatively with endothelin-1 (ET-1) (P < 0.05). FMD and NO correlated negatively with diabetes duration/HbA1c (P < 0.05), whereas ET-1 correlated positively with glycosylated hemoglobinA1c (HbA1c)/diabetes duration (P < 0.05). Pulmonary functional indexes negatively correlated with HbA1c/diabetes duration (P < 0.05). Multiple linear regression was used to analyze the relationship between vascular endothelial function indexes (FMD, ET-1, and NO) and pulmonary functional indexes. The results indicated that each vascular endothelial function index (FMD, ET-1, and NO) was significantly correlated with the pulmonary functional index (P < 0.05). The patients with T2DM presented changes in the subclinical vascular endothelial and pulmonary function. They also had impaired vascular endothelial functions, which were characterized by reduced vascular endothelial function relative to those of healthy people. Regulating glycemia may improve vascular endothelial and pulmonary functions. Moreover, microvascular lesions in preclinical stages, vascular endothelial function indexes (FMD, ET-1, and NO) were valid predictors of alterations in pulmonary function in T2DM patients without related complications.Clinical Trial RegistrationClinicalTrials.gov, identifier NCT03575988. |
| Databáze: | OpenAIRE |
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